Evidence map›Paper›PMID 30808897›Full record

ArticleScientific reports2019

Cavitation dose painting for focused ultrasound-induced blood-brain barrier disruption.

Yaoheng Yang, Xiaohui Zhang, Dezhuang Ye, Richard Laforest, Jeffrey Williamson, Yongjian Liu, Hong Chen

Abstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Ultrasound-responsive composite hydrogels: Design rules for spatiotemporally controlled drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2026
    Review
  2. Article
  3. Article
  4. Overview of Therapeutic Ultrasound Applications and Safety Considerations: 2024 Update.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Therapeutic ultrasound transducer technology and monitoring techniques: a review with clinical examples.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2024
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Robotic device for transcranial focussed ultrasound applications in small animal models.The international journal of medical robotics + computer assisted surgery : MRCAS · 2022
    Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yaoheng YangDepartment of Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO, 63130, USA.
Xiaohui ZhangMallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO, 63110, USA.
Dezhuang YeDepartment of Mechanical Engineering and Materials Science, Washington University in St. Louis, Saint Louis, MO, 63130, USA.
Richard LaforestMallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO, 63110, USA.
Jeffrey WilliamsonDepartment of Radiation Oncology, Washington University School of Medicine, Saint Louis, MO, 63108, USA.
Yongjian LiuMallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO, 63110, USA.ORCID 0000-0002-1118-1535
Hong ChenDepartment of Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO, 63130, USA. hongchen@wustl.edu.

Funding

Image-guided focused ultrasound-mediated intranasal brain drug delivery technique (FUSIN)R01EB027223 · NIBIB · WASHINGTON UNIVERSITY · PI Hong Chen · 2019 to 2026
$4.3M
FOCUS: FUNCTIONAL OPTICAL IMAGING FEEDBACK-CONTROLLED CELLULAR-LEVEL ULTRASOUND STIMULATIONR01MH116981 · NIMH · WASHINGTON UNIVERSITY · PI CHEN, HONG · 2018 to 2021
$2.8M
NIBIB NIH HHS R01 EB027223NIMH NIH HHS R01 MH116981
6 · The paper itself

Abstract

Focused ultrasound combined with microbubble for blood-brain barrier disruption (FUS-BBBD) is a promising technique for noninvasive and localized brain drug delivery. This study demonstrates that passive cavitation imaging (PCI) is capable of predicting the location and concentration of nanoclusters delivered by FUS-BBBD. During FUS-BBBD treatment of mice, the acoustic emissions from FUS-activated microbubbles were passively detected by an ultrasound imaging system and processed offline using a frequency-domain PCI algorithm. After the FUS treatment, radiolabeled gold nanoclusters,

Indexed as

UltrasonicsAnimalsBlood-Brain BarrierDrug Delivery SystemsGoldMetal NanoparticlesMicePositron Emission Tomography Computed TomographyGold

Identifiers

PMID30808897
PMCPMC6391404

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.