Evidence map›Paper›PMID 30808868›Full record

ArticleBlood cancer journal2019

The role of cement augmentation with percutaneous vertebroplasty and balloon kyphoplasty for the treatment of vertebral compression fractures in multiple myeloma: a consensus statement from the International Myeloma Working Group (IMWG).

Charalampia Kyriakou, Sean Molloy, Frank Vrionis, Ronald Alberico, Leonard Bastian, Jeffrey A Zonder, Sergio Giralt, Noopur Raje, Robert A Kyle, David G D Roodman and 4 more

Open access · goldAbstract readConsensus Statement
In one paragraph

Article in Blood cancer journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 2 pooled it
10.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 101 citations in OpenAlex.

  1. International Myeloma Working Group Recommendations for the Diagnosis and Management of Solitary Plasmacytomas.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2026
    Guideline
  2. Guideline
  3. Review
  4. Article
  5. Review
  6. Systemic bone loss measured by routine CT is associated with increased pain, postural decompensation, and survival in multiple myeloma.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Analysis of the efficacy of separation surgery for severe neurological compression in multiple myeloma: a retrospective analysis of 35 cases.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2024
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 12 institutions in 4 countries.

Charalampia KyriakouUniversity College London and Northwick Park Hospitals, London, UK. c.kyriakou@nhs.net.
Sean MolloyRoyal National Orthopedic Hospital, Stanmore, UK.
Frank VrionisMoffitt Cancer Center, University of South Florida, Tampa, FL, USA.
Ronald AlbericoRoswell Park Cancer Center, Buffalo, NY, USA.
Leonard BastianKlinikum Leverkusen, Leverkusen, Germany.
Jeffrey A ZonderKarmanos Cancer Institute, Detroit, MI, USA.
Sergio GiraltMemorial Sloan-Kettering Cancer Center, New York, NY, USA.
Noopur RajeMassachusetts General Hospital, Boston, MA, USA.
Robert A KyleDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
David G D RoodmanIndiana University, Indianapolis, IN, USA.
Meletios A DimopoulosUniversity of Athens School of Medicine, Athens, Greece.
S Vincent RajkumarMayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-5862-1833
Brian B G DurieCedars-Sinai Samuel Oschin Cancer Center, Los Angeles, CA, USA.
Evangelos TerposUniversity of Athens School of Medicine, Athens, Greece.ORCID http://orcid.org/0000-0001-5133-1422
Mayo Clinic in Arizona · USNational and Kapodistrian University of Athens · GRCedars-Sinai Medical Center · USIndiana University – Purdue University Indianapolis · USKlinikum Leverkusen · DELondon North West Healthcare NHS Trust · GBMassachusetts General Hospital · USMemorial Sloan Kettering Cancer Center · USRoswell Park Comprehensive Cancer Center · USRoyal National Orthopaedic Hospital · GBThe Barbara Ann Karmanos Cancer Institute · USUniversity of South Florida · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Project 4: Targeting Resistance to T-Cell Directed Therapy in Multiple MyelomaP50CA186781 · NCI · MAYO CLINIC ARIZONA · PI Rafael Fonseca · 2015 to 2026
$25.5M
NCI NIH HHS P30 CA008748NCI NIH HHS P50 CA186781
6 · The paper itself

Abstract

Multiple myeloma (MM) represents approximately 15% of haematological malignancies and most of the patients present with bone involvement. Focal or diffuse spinal osteolysis may result in significant morbidity by causing painful progressive vertebral compression fractures (VCFs) and deformities. Advances in the systemic treatment of myeloma have achieved high response rates and prolonged the survival significantly. Early diagnosis and management of skeletal events contribute to improving the prognosis and quality of life of MM patients. The management of patients with significant pain due to VCFs in the acute phase is not standardised. While some patients are successfully treated conservatively, and pain relief is achieved within a few weeks, a large percentage has disabling pain and morbidity and hence they are considered for surgical intervention. Balloon kyphoplasty and percutaneous vertebroplasty are minimally invasive procedures which have been shown to relieve pain and restore function. Despite increasing positive evidence for the use of these procedures, the indications, timing, efficacy, safety and their role in the treatment algorithm of myeloma spinal disease are yet to be elucidated. This paper reports an update of the consensus statement from the International Myeloma Working Group on the role of cement augmentation in myeloma patients with VCFs.

Indexed as

KyphoplastyBone CementsClinical Decision-MakingDecision TreesDisease ManagementFemaleFractures, CompressionHumansMaleMultiple MyelomaSpinal FracturesTreatment OutcomeVertebroplastyBone Cements

Identifiers

PMID30808868
PMCPMC6391474
OpenAlexW2917065764

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.