ArticleProceedings of the National Academy of Sciences of the United States of America2019
Basolateral amygdala input to the medial prefrontal cortex controls obsessive-compulsive disorder-like checking behavior.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
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45citing papers in PubMed, 1 pooled it
7.5field-weighted citation impact, top 3% of its field
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Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Invasive and Non-invasive Neurostimulation for OCD.Current topics in behavioral neurosciences · 2021Pooled it
- Acupuncture modulates emotional network resting-state functional connectivity in patients with insomnia disorder: a randomized controlled trial and fMRI study.BMC complementary medicine and therapies · 2024Trial
- Social isolation recruits amygdala-medial prefrontal cortex projections to escalate alcohol drinking in male mice.Nature neuroscience · 2026Article
- A basolateral amygdala to dorsolateral striatum projection modulates stimulus-evoked motor behavior.Neuron · 2026Article
- Decoding the Neural Circuit Underlying Context-Cue Association in Retrieval of Morphine Reward Memory.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Effective connectivity in cortical and subcortical visual fear processing networks during fearful face viewing in body dysmorphic disorder.Research square · 2026Article
- Multi-connectomics underpin emotional dysfunction in mouse exposed to simulated space composite environment.Translational psychiatry · 2025Article
- Dissociating the Effects of Light at Night from Circadian Misalignment in a Neurodevelopmental Disorder Mouse Model Using Ultradian Light-Dark Cycles.Clocks & sleep · 2025Article
- IRF8 deficiency causes anxiety-like behavior in a sex-dependent manner.bioRxiv : the preprint server for biology · 2025Article
- Suppression of mPFC-Amygdala Circuit Mitigates Sevoflurane-Induced Cognitive Deficits in Aged Mice.CNS neuroscience & therapeutics · 2025Article
- Early Life Stress Impairs VTA Coordination of BLA Network and Behavioral States.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Raptin, a sleep-induced hypothalamic hormone, suppresses appetite and obesity.Cell research · 2025Article
- Rescue-like behavior in a bystander mouse toward anesthetized conspecifics promotes arousal via a tongue-brain connection.Science advances · 2025Article
- AMPA/kainate receptor activation within the prelimbic cortex is necessary for incubated cocaine-craving.Frontiers in psychiatry · 2025Article
- Brain structural changes in girls with idiopathic central precocious puberty: a voxel-based morphometry and surface-based morphometry analysis.Frontiers in endocrinology · 2025Article
- Efficacy of Acupuncture Therapy in Treating Non-Motor Symptoms of Parkinson's Disease: A Systematic Review and Network Meta-Analysis.Neuropsychiatric disease and treatment · 2025Review
- Neurobiology of Obsessive-Compulsive Disorder from Genes to Circuits: Insights from Animal Models.Neuroscience bulletin · 2024Review
- Impaired neural circuitry of hippocampus in Pax2 nervous system-specific knockout mice leads to restricted repetitive behaviors.CNS neuroscience & therapeutics · 2024Article
- Basolateral amygdala neuropeptide Y system modulates binge ethanol consumption.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Selective alterations of endocannabinoid system genes expression in obsessive compulsive disorder.Translational psychiatry · 2024Article
Corrections and comments
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Authors and funding
21 authors at 7 institutions in 1 country.
Tingting SunHefei National Laboratory for Physical Sciences at the Microscale, Department of Biophysics and Neurobiology, University of Science and Technology of China, Hefei, Anhui 230027, People's Republic of China.
Zihua SongHefei National Laboratory for Physical Sciences at the Microscale, Department of Biophysics and Neurobiology, University of Science and Technology of China, Hefei, Anhui 230027, People's Republic of China.
Yanghua TianDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, People's Republic of China.
Wenbo TianHefei National Laboratory for Physical Sciences at the Microscale, Department of Biophysics and Neurobiology, University of Science and Technology of China, Hefei, Anhui 230027, People's Republic of China.
Chunyan ZhuDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, People's Republic of China.
Gongjun JiDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, People's Republic of China.
Yudan LuoDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, People's Republic of China.
Shi ChenDepartment of Pain Management, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, People's Republic of China.
Likui WangDepartment of Pain Management, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, People's Republic of China.
Yu MaoHefei National Laboratory for Physical Sciences at the Microscale, Department of Biophysics and Neurobiology, University of Science and Technology of China, Hefei, Anhui 230027, People's Republic of China.
Wen XieDepartment of Psychology, Anhui Mental Health Center, Hefei, Anhui 230026, People's Republic of China.
Hui ZhongDepartment of Psychology, Anhui Mental Health Center, Hefei, Anhui 230026, People's Republic of China.
Fei ZhaoState Key Laboratory of Virology, Chinese Academy of Sciences Center for Excellence in Brain Science and Intelligence Technology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, People's Republic of China.
Min-Hua LuoState Key Laboratory of Virology, Chinese Academy of Sciences Center for Excellence in Brain Science and Intelligence Technology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, People's Republic of China.
Wenjuan TaoHefei National Laboratory for Physical Sciences at the Microscale, Department of Biophysics and Neurobiology, University of Science and Technology of China, Hefei, Anhui 230027, People's Republic of China.
Haitao WangHefei National Laboratory for Physical Sciences at the Microscale, Department of Biophysics and Neurobiology, University of Science and Technology of China, Hefei, Anhui 230027, People's Republic of China.
Jie LiHefei National Laboratory for Physical Sciences at the Microscale, Department of Biophysics and Neurobiology, University of Science and Technology of China, Hefei, Anhui 230027, People's Republic of China.
Juan LiHefei National Laboratory for Physical Sciences at the Microscale, Department of Biophysics and Neurobiology, University of Science and Technology of China, Hefei, Anhui 230027, People's Republic of China.
Jiangning ZhouHefei National Laboratory for Physical Sciences at the Microscale, Department of Biophysics and Neurobiology, University of Science and Technology of China, Hefei, Anhui 230027, People's Republic of China.
Kai WangDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, People's Republic of China; wangkai1964@126.com zhizhang@ustc.edu.cn.
Zhi ZhangHefei National Laboratory for Physical Sciences at the Microscale, Department of Biophysics and Neurobiology, University of Science and Technology of China, Hefei, Anhui 230027, People's Republic of China; wangkai1964@126.com zhizhang@ustc.edu.cn.
First Affiliated Hospital of Anhui Medical University · CNUniversity of Science and Technology of China · CNHefei National Center for Physical Sciences at Nanoscale · CNAnhui Medical University · CNAnhui Mental Health Center · CNCenter for Excellence in Brain Science and Intelligence Technology · CNChinese Academy of Sciences · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obsessive-compulsive disorder (OCD) affects ∼1 to 3% of the world's population. However, the neural mechanisms underlying the excessive checking symptoms in OCD are not fully understood. Using viral neuronal tracing in mice, we found that glutamatergic neurons from the basolateral amygdala (BLA
Indexed as
AmygdalaAnimalsBasolateral Nuclear ComplexDisease Models, AnimalGlutamic AcidHumansMagnetic Resonance ImagingMiceNeural PathwaysNeuronsObsessive-Compulsive DisorderPrefrontal CortexGlutamic AcidBLAmPFCneural circuitOCD checking symptoms
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.