ArticleBlood advances2019
Inhibition of contact-mediated activation of factor XI protects baboons against
Erratum issuedOpen access · goldAbstract read
In one paragraph
Article in Blood advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 58 papers.
0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
5.6field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 74 citations in OpenAlex.
- Factor XI Inhibition for the Prevention of Catheter-Associated Thrombosis in Patients With Cancer Undergoing Central Line Placement: A Phase 2 Clinical Trial.Arteriosclerosis, thrombosis, and vascular biology · 2024Trial
- Trial
- Therapeutic Potential of C1-Inhibitor in Vascular Diseases and Beyond.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Anthrax toxins exacerbate sepsis-induced coagulopathy and endothelial dysfunction in a baboon model of anthrax.Journal of thrombosis and haemostasis : JTH · 2026Article
- An antibody targeting high-molecular-weight kininogen blocks contact system activation in a model of polymicrobial sepsis.Journal of thrombosis and haemostasis : JTH · 2025Article
- Bacterial infection and activation of the contact pathway of coagulation.Blood vessels, thrombosis & hemostasis · 2025Review
- Protective effects of factor XI inhibition by abelacimab in a baboon model of live Staphylococcus aureus sepsis.Journal of thrombosis and haemostasis : JTH · 2025Article
- New mechanisms and therapeutic approaches to regulate vascular permeability in systemic inflammation.Current opinion in hematology · 2025Review
- Activation of the Coagulation Cascade as a Universal Danger Sign.Current issues in molecular biology · 2025Review
- The role of programmed cell death in organ dysfunction induced by opportunistic pathogens.Critical care (London, England) · 2025Review
- The physicochemical properties of lipopolysaccharide chemotypes regulate activation of the contact pathway of blood coagulation.The Journal of biological chemistry · 2025Article
- Acetaminophen Overdose Reveals PAR4 as a Low-Expressing but Potent Receptor on the Hepatic Endothelium in Mice.Arteriosclerosis, thrombosis, and vascular biology · 2025Article
- Coagulation factor XI regulates endothelial cell permeability and barrier function in vitro and in vivo.Blood · 2024Article
- Hemostasis and complement in allogeneic hematopoietic stem cell transplantation: clinical significance of two interactive systems.Bone marrow transplantation · 2024Review
- Pathophysiological dynamics in the contact, coagulation, and complement systems during sepsis: Potential targets for nafamostat mesilate.Journal of intensive medicine · 2024Review
- The Interaction of Complement and Intrinsic Coagulation System: A Comparative Study between COVID-19 and Bacterial Sepsis Patients.Journal of clinical medicine · 2024Article
- Thromboinflammation and the Role of Platelets.Arteriosclerosis, thrombosis, and vascular biology · 2024Article
- Review
- Biology of factor XI.Blood · 2024Review
- Activation of coagulation FXI promotes endothelial inflammation and amplifies platelet activation in a nonhuman primate model of hyperlipidemia.Research and practice in thrombosis and haemostasis · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
15 authors at 6 institutions in 3 countries.
Robert SilasiCardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK.ORCID 0000-0001-9590-6160
Ravi Shankar KeshariCardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK.ORCID 0000-0002-4177-9095
Cristina LupuCardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK.ORCID 0000-0001-8619-0893
Walter Janse Van RensburgHuman Molecular Biology Unit, University of the Free State, Bloemfontein, South Africa.ORCID 0000-0001-9088-6199
Hala ChaabanNeonatal and Perinatal Section, Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK.ORCID 0000-0002-7112-564X
Girija RegmiCardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK.ORCID 0000-0001-6827-3783
Aleksandr ShamanaevDepartment of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0003-2348-1444
Joseph J ShatzelDepartment of Biomedical Engineering and.
Cristina PuyDepartment of Biomedical Engineering and.
Christina U LorentzDepartment of Biomedical Engineering and.
Erik I TuckerDepartment of Biomedical Engineering and.
David GailaniDepartment of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0001-8142-8014
András GruberDepartment of Biomedical Engineering and.ORCID 0000-0001-6212-2247
Owen J T McCartyDepartment of Biomedical Engineering and.ORCID 0000-0001-9481-0124
Florea LupuCardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK.ORCID 0000-0003-1249-9278
Oklahoma Medical Research Foundation · USOregon Health & Science University · USAronora (United States) · USVanderbilt University Medical Center · USUniversity of Oklahoma Health Sciences Center · USUniversity of the Free State · ZA
Funding
Translation of immunologic technologies from basic research into pre-clinical nonU19AI062629 · NIAID · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI COGGESHALL, KENNETH MARK · 2004 to 2023
$56.2MCharacterization of Coagulation Factor-platelet Interactions: Role of FXIR01HL101972 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Owen J McCarty · 2010 to 2026
$8.5MPilot ProjectP30GM114731 · NIGMS · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI MCEVER, RODGER PAUL · 2016 to 2020
$6.5MBiochemistry and Pathophysiology of Factor XI and Contact ActivationR35HL140025 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GAILANI, DAVID · 2018 to 2024
$5.5MFactor XI inhibitor for thrombosisR44HL106919 · NHLBI · ARONORA, INC. · PI LORENTZ, CHRISTINA U, TUCKER, ERIK IAN · 2012 to 2019
$5.0MTherapeutic factor XI blockade for sepsisR44AI088937 · NIAID · ARONORA, INC. · PI GRUBER, ANDRAS, TUCKER, ERIK IAN · 2012 to 2014
$3.0MTherapeutic factor XI blockade for sepsisR44HL128016 · NHLBI · ARONORA, INC. · PI GRUBER, ANDRAS, TUCKER, ERIK IAN · 2015 to 2017
$2.4MFXI and SepsisR01GM116184 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI LUPU, FLOREA, MCCARTY, OWEN J · 2015 to 2018
$1.9MCoagulation and Complement Activation in SepsisR01GM121601 · NIGMS · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI LUPU, FLOREA · 2017 to 2020
$1.6MFactor XI Inhibition for the Treatment of Ischemic StrokeR43NS077600 · NINDS · ARONORA, INC. · PI LEUNG, PHILBERTA YUENHUI, TUCKER, ERIK IAN · 2012 to 2012
$316kFactor XI inhibitor for thrombosisR43HL106919 · NHLBI · ARONORA, INC. · PI TUCKER, ERIK IAN · 2011 to 2011
$310kTherapeutic factor XI blockade for sepsisR43AI088937 · NIAID · ARONORA, INC. · PI GRUBER, ANDRAS, TUCKER, ERIK IAN · 2010 to 2010
$297kNHLBI NIH HHS R01 HL101972NHLBI NIH HHS R35 HL140025NHLBI NIH HHS R43 HL106919NHLBI NIH HHS R44 HL106919NHLBI NIH HHS R44 HL128016NIAID NIH HHS R43 AI088937NIAID NIH HHS R44 AI088937NIAID NIH HHS U19 AI062629NIGMS NIH HHS P30 GM114731NIGMS NIH HHS R01 GM116184NIGMS NIH HHS R01 GM121601NINDS NIH HHS R43 NS077600
Abstract
PubMed holds no abstract for this paper.
Indexed as
AnimalsAntibodies, Monoclonal, HumanizedBlood CoagulationFactor XIFactor XIIaHumansPapio ursinusSepsisStaphylococcal InfectionsStaphylococcus aureusAntibodies, Monoclonal, HumanizedFactor XIFactor XIIa
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.