Evidence map›Paper›PMID 30808658›Full record

ArticleGenes & development2019

Rapid embryonic cell cycles defer the establishment of heterochromatin by Eggless/SetDB1 in

Charles A Seller, Chun-Yi Cho, Patrick H O'Farrell

Open access · diamondAbstract read
In one paragraph

Article in Genes & development, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 94 citations in OpenAlex.

  1. Cross-species incompatibilities offer new insights into the functional consequences of satellite DNA evolution.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2026
    Review
  2. Review
  3. Article
  4. bioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. bioRxiv : the preprint server for biology · 2026
    Article
  7. Maternal IntS11 primes embryonic totipotency by organizing early zygotic transcription initiation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Heterochromatin-based silencing of a foreign tandem repeat inbioRxiv : the preprint server for biology · 2025
    Article
  12. Cell-cycle-regulated transcriptional pausing ofMolecular biology of the cell · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Cell cycle-regulated transcriptional pausing ofbioRxiv : the preprint server for biology · 2024
    Article
  17. Article
  18. HIRA and dPCIF1 coordinately establish totipotent chromatin and control orderly ZGA inProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  19. Review
  20. Article

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Charles A SellerDepartment of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, California 94143, USA.
Chun-Yi ChoDepartment of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, California 94143, USA.
Patrick H O'FarrellDepartment of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, California 94143, USA.ORCID 0000-0003-0011-2734
University of California, San Francisco · US

Funding

GENETICS OF EUCARYOTIC AND PROCARYOTIC ORGANISMST32GM007810 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ASHRAFI, KAVEH, NARLIKAR, GEETA J · 1985 to 2020
$15.1M
Developmental Programs of Cell Cycle ControlR37GM037193 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI O'FARRELL, PATRICK H · 2010 to 2019
$4.8M
MOLECULAR DETERMINANTS OF DEVELOPMENTAL FATER01GM037193 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI O'FARRELL, PATRICK H · 1986 to 2009
$4.4M
NIGMS NIH HHS R01 GM037193NIGMS NIH HHS R37 GM037193NIGMS NIH HHS T32 GM007810
6 · The paper itself

Abstract

Acquisition of chromatin modifications during embryogenesis distinguishes different regions of an initially naïve genome. In many organisms, repetitive DNA is packaged into constitutive heterochromatin that is marked by di/trimethylation of histone H3K9 and the associated protein HP1a. These modifications enforce the unique epigenetic properties of heterochromatin. However, in the early

Indexed as

Gene Expression Regulation, DevelopmentalAnimalsCell CycleDrosophila melanogasterDrosophila ProteinsHeterochromatinHistone-Lysine N-MethyltransferaseTime FactorsDrosophila Proteinsegg protein, DrosophilaHeterochromatinHistone-Lysine N-Methyltransferasecell cycledevelopmentembryoheterochromatin

Identifiers

PMID30808658
PMCPMC6446540
OpenAlexW2897575264

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.