Evidence map›Paper›PMID 30808572›Full record

ArticleDigestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver2019

Association between non-invasive liver fibrosis scores and occurrence of health adverse outcomes in older people.

Antonio De Vincentis, Luisa Costanzo, Umberto Vespasiani-Gentilucci, Antonio Picardi, Stefania Bandinelli, Luigi Ferrucci, Raffaele Antonelli Incalzi, Claudio Pedone

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Article in Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Antonio De VincentisGeriatric and Gerontology Department, Campus Bio-Medico University, Rome, Italy; Clinical Medicine and Hepatology Department, Campus Bio-Medico University, Rome, Italy. Electronic address: a.devincentis@unicampus.it.
Luisa CostanzoGeriatric and Gerontology Department, Campus Bio-Medico University, Rome, Italy.
Umberto Vespasiani-GentilucciClinical Medicine and Hepatology Department, Campus Bio-Medico University, Rome, Italy.
Antonio PicardiClinical Medicine and Hepatology Department, Campus Bio-Medico University, Rome, Italy.
Stefania BandinelliLocal Health Agency of Florence, Florence, Italy.
Luigi FerrucciNational Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America.
Raffaele Antonelli IncalziGeriatric and Gerontology Department, Campus Bio-Medico University, Rome, Italy.
Claudio PedoneGeriatric and Gerontology Department, Campus Bio-Medico University, Rome, Italy.

Funding

Oxidative stress and the pathogenesis of sarcopenia and disability in older womenR01AG027012 · NIA · JOHNS HOPKINS UNIVERSITY · PI SEMBA, RICHARD D · 2005 to 2018
$3.6M
Hepcidin and the pathogenesis of anemia in older adults.R01AG029148 · NIA · JOHNS HOPKINS UNIVERSITY · PI SEMBA, RICHARD D · 2007 to 2010
$1.2M
NIA NIH HHS R01 AG027012NIA NIH HHS R01 AG029148
6 · The paper itself

Abstract

backgroundThe relation between liver fibrosis scores and health outcomes in older people has been barely investigated. We aimed to evaluate the association of four liver fibrosis scores (fibrosis-4 -FIB-4-, NAFLD fibrosis score -NFS-, BARD and aspartate aminotransferase/alanine aminotransferase ratio -AST/ALT-) with mortality and incident disability at 6 years in an older population.

methodsWe studied 962 individuals aged ≥65 (mean age 74.4; female 55.5%) with a mean follow-up of 95.7 months, enrolled in the InCHIANTI study. The relationship between liver fibrosis scores and mortality and disability was assessed through Cox and log-binomial regressions.

resultsNFS and FIB-4 were associated with higher overall (aHR ranging 1.38-1.78 for intermediate risk of fibrosis and 1.60-2.02 for high risk) and cardiovascular (aHR ranging 1.76-2.90 for intermediate and 2.22-2.42 for high risk) mortality. AST/ALT and BARD were only associated with overall mortality. Only NFS and FIB-4 high risk classes were associated with incident disability (aRR ranging 1.93-2.76). Despite poor sensitivity, all scores showed high specificity (ranging 0.88-0.95).

conclusionHigher risk of liver fibrosis is associated with higher risk of poor health outcomes. Liver fibrosis scores may help to stratify the risk and, mainly, identify elderly patients with favorable prognosis.

Indexed as

Risk AssessmentAgedComorbidityDisease ProgressionFibrosisFrailtyHumansLiverOutcome Assessment, Health CareProspective StudiesSarcopeniaDisabilityElderlyLiver fibrosis scoresMortality

Identifiers

PMID30808572
PMCPMC6679815

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.