ArticleEnvironment international2018
Urinary concentrations and profiles of organophosphate and pyrethroid pesticide metabolites and phenoxyacid herbicides in populations in eight countries.
Article in Environment international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 106 citations in OpenAlex.
- A systematic review of organophosphorus pesticides detection in biological matrices.Forensic science, medicine, and pathology · 2025Pooled it
- Development and application of a sensitive method for urinary biomonitoring of microcystin-LR: association with semen quality in adult men.Journal of exposure science & environmental epidemiology · 2026Article
- Urine glyphosate levels and kidney function outcomes in a cohort study of workers in El Salvador and Nicaragua.Journal of exposure science & environmental epidemiology · 2026Article
- Psychiatric Risk Implications From Behavioral and Neural Effects of Adolescent Exposure to Environmental Insecticides: A Systematic Review of Rodent Studies.Biological psychiatry · 2026Review
- SPE-UHPLC-MS/MS Method for Simultaneous Quantification of 50 Pesticide Biomarkers Across Nine Current-Use Chemical Classes in Human Urine.Journal of xenobiotics · 2026Article
- Prenatal Exposure to Organochlorine Compounds and Other Pesticides: A Systematic Review of Neonatal Health Outcomes.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2026Article
- Male partner pesticide residue exposure from fruit and vegetable intake in relation to outcomes of infertility treatment: a prospective cohort study.The American journal of clinical nutrition · 2025Article
- Global Evidence on Monitoring Human Pesticide Exposure.Journal of xenobiotics · 2025Review
- Article
- Associations of Pesticide Residue Exposure from Fruit and Vegetable Intake with Ovarian Reserve.The Journal of nutrition · 2025Article
- Reference values of urinary metabolites of organophosphate in healthy Iranian adults.PloS one · 2025Article
- Current-use pesticide exposures in remote Inuit communities.International journal of circumpolar health · 2024Article
- Pesticide exposure and asthma morbidity in children residing in urban, multi-family housing.Journal of exposure science & environmental epidemiology · 2024Article
- Determination of pesticide residues in urine by chromatography-mass spectrometry: methods and applications.Frontiers in public health · 2024Review
- The epidemiology of cryptorchidism and potential risk factors, including endocrine disrupting chemicals.Frontiers in endocrinology · 2024Review
- Article
- Association of Prenatal Exposure to Organophosphate, Pyrethroid, and Neonicotinoid Insecticides with Child Neurodevelopment at 2 Years of Age: A Prospective Cohort Study.Environmental health perspectives · 2023Article
- Effects of prenatal pesticide exposure on the fetal brain and placenta transcriptomes in a rodent model.Toxicology · 2023Article
- Organophosphate Pesticides and Pyrethroids in Farmland of the Pearl River Delta, China: Regional Residue, Distributions and Risks.International journal of environmental research and public health · 2023Article
- Frequency of urinary pesticides in children: a scoping review.Frontiers in public health · 2023Article
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Concentrations of nine metabolites of organophosphate and pyrethroid insecticides, as well as two phenoxy herbicides, were determined in 322 urine samples collected from eight countries during 2006-2014 by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). The target pesticides were found ubiquitously, indicating widespread exposure of humans to pesticides in these countries. The highest sum concentrations of 11 pesticides were found in urine collected from Vietnam (median, 28.9 ng/mL), followed in decreasing order by samples from India (14.2 ng/mL), China (13.6 ng/mL), Korea (12.5 ng/mL), Greece (12.3 ng/mL), Saudi Arabia (11.3 ng/mL), the USA (7.9 ng/mL), and Japan (7.1 ng/mL). Organophosphorus compounds accounted for 62-77% of the total urinary pesticide concentrations. Para-nitrophenol (metabolite of parathion and methyl parathion) and 3,5,6-trichloro-2-pyridinol (metabolite of chlorpyrifos and chlorpyrifos-methyl) were the major metabolites, especially in India (72%), China (69%), and Greece (66%). Differences in urinary pesticide concentrations between genders (male vs. female), age groups (categorized as ≤20, 21-49, and ≥50 years), and cities (Guangzhou, Shanghai, and Qiqihar) were examined. On the basis of the concentrations measured in urine, total daily intakes (DIs) of pesticides were estimated. The DIs of chlorpyrifos were found to be higher for populations in Vietnam, Greece, India, China, and Korea (≥9.6 μg/day) than those estimated for the other countries (<5 μg/day). The DIs of parathion (≥9.6 μg/day) in populations of China, India, and Korea were higher than those estimated for the other countries (5.7-9.3 μg/day). This is the first study to establish baseline levels of exposure of a variety of pesticides in several Asian countries.
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