ArticleActa veterinaria Scandinavica2019
Plasma metabolomics reveals lower carnitine concentrations in overweight Labrador Retriever dogs.
Article in Acta veterinaria Scandinavica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 17 citations in OpenAlex.
- Dynamic shifts in the serum lipidome of dogs with obesity before and after weight loss: a pilot study.Journal of animal science · 2026Article
- Metabolic profiles show few differences in serum amino acid, one-carbon, and fatty acid compounds in dogs fed a plant-based ("vegan") or meat-based diet.Frontiers in veterinary science · 2025Article
- Replacement of Dietary Carbohydrate with Protein versus Fat Differentially Alters Postprandial Circulating Hormones and Macronutrient Metabolism in Dogs.Metabolites · 2024Article
- Different Diet Energy Levels Alter Body Condition, Glucolipid Metabolism, Fecal Microbiota and Metabolites in Adult Beagle Dogs.Metabolites · 2023Article
- Profound Perturbation in the Metabolome of a Canine Obesity and Metabolic Disorder Model.Frontiers in endocrinology · 2022Article
- Effect of 6-Month Feeding with a Diet Enriched in EPA + DHA from Fish Meat on the Blood Metabolomic Profile of Dogs with Myxomatous Mitral Valve Disease.Animals : an open access journal from MDPI · 2021Article
- Addition of dietary methionine but not dietary taurine or methyl donors/receivers to a grain-free diet increases postprandial homocysteine concentrations in adult dogs.Journal of animal science · 2021Article
- Evaluation of Changes in Metabolites of Saliva in Canine Obesity Using a Targeted Metabolomic Approach.Animals : an open access journal from MDPI · 2021Article
- Effects of Weight Loss and Moderate-Protein, High-Fiber Diet Consumption on the Fasted Serum Metabolome of Cats.Metabolites · 2021Article
- Metabolomics shows the Australian dingo has a unique plasma profile.Scientific reports · 2021Article
- Serum metabolomics analysis reveals that weight loss in obese dogs results in a similar metabolic profile to dogs in ideal body condition.Metabolomics : Official journal of the Metabolomic Society · 2021Article
- Enhancing Fatty Acids OxidationFrontiers in pharmacology · 2021Article
- Metabogenomics reveals four candidate regions involved in the pathophysiology of Equine Metabolic Syndrome.Molecular and cellular probes · 2020Article
- Metabolic Profiling of Plasma in Different Calving Body Condition Score Cows Using an Untargeted Liquid Chromatography-Mass Spectrometry Metabolomics Approach.Animals : an open access journal from MDPI · 2020Article
- Article
- What do Brazilian owners know about canine obesity and what risks does this knowledge generate?PloS one · 2020Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe prevalence of overweight is increasing in dogs, but the metabolic events related to this condition are still poorly understood. The purpose of the study was to investigate the postprandial response of plasma metabolites using a meal-challenge test and to identify metabolic variations related to spontaneous overweightness in privately owned dogs.
resultsTwenty-eight healthy male intact Labrador Retriever dogs were included, 12 of which were classified as lean (body condition score (BCS) 4-5 on a 9-point scale) and 16 as overweight (BCS 6-8). After an overnight fast (14-17 h), blood samples were collected and dogs were thereafter fed a high-fat meal. Postprandial blood samples were collected hourly four times. Plasma metabolites were identified by nuclear magnetic resonance. Postprandial metabolomes differed from the fasting metabolome in multivariate discriminant analysis (PLS-DA: Q
conclusionsA postprandial amino acid response was detected but no time-dependent variations with regards to body condition groups were found. Lower carnitine concentrations were found in overweight compared to lean dogs. The latter finding could indicate a carnitine insufficiency related to spontaneous adiposity and altered lipid metabolism in overweight dogs in this cohort of otherwise healthy Labrador Retrievers.
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