Evidence map›Paper›PMID 30808357›Full record

ReviewMicrobial cell factories2019

Metabolic engineering of microorganisms for production of aromatic compounds.

Damla Huccetogullari, Zi Wei Luo, Sang Yup Lee

Open access · goldAbstract readReview
In one paragraph

Review in Microbial cell factories, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed
9.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 224 citations in OpenAlex.

  1. Article
  2. EngineeringMetabolic engineering communications · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Advances in microbial biosynthesis of indirubin.Chinese herbal medicines · 2026
    Review
  8. Review
  9. Microbial Metabolism: Primary and Secondary Metabolites.Progress in molecular and subcellular biology · 2026
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Modular pathway engineering for enhanced production ofApplied and environmental microbiology · 2025
    Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Damla HuccetogullariMetabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering (BK21 Plus Program) and Institute for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea.
Zi Wei LuoMetabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering (BK21 Plus Program) and Institute for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea.
Sang Yup LeeMetabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering (BK21 Plus Program) and Institute for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea. leesy@kaist.ac.kr.ORCID http://orcid.org/0000-0003-0599-3091
Korea Advanced Institute of Science and Technology · KR

Funding

Ministry of Science and ICT 2011-0031963Ministry of Science and ICT NRF-2012M1A2A2026556
6 · The paper itself

Abstract

Metabolic engineering has been enabling development of high performance microbial strains for the efficient production of natural and non-natural compounds from renewable non-food biomass. Even though microbial production of various chemicals has successfully been conducted and commercialized, there are still numerous chemicals and materials that await their efficient bio-based production. Aromatic chemicals, which are typically derived from benzene, toluene and xylene in petroleum industry, have been used in large amounts in various industries. Over the last three decades, many metabolically engineered microorganisms have been developed for the bio-based production of aromatic chemicals, many of which are derived from aromatic amino acid pathways. This review highlights the latest metabolic engineering strategies and tools applied to the biosynthesis of aromatic chemicals, many derived from shikimate and aromatic amino acids, including L-phenylalanine, L-tyrosine and L-tryptophan. It is expected that more and more engineered microorganisms capable of efficiently producing aromatic chemicals will be developed toward their industrial-scale production from renewable biomass.

Indexed as

Metabolic EngineeringAmino Acids, AromaticBacteriaBiomassIndustrial MicrobiologyOrganic ChemicalsPhenylalanineShikimic AcidTryptophanTyrosineAmino Acids, AromaticOrganic ChemicalsPhenylalanineShikimic AcidTryptophanTyrosineAromatic compoundsMetabolic engineeringPhenylalanineShikimate pathwaySynthetic biologyTryptophanTyrosine

Identifiers

PMID30808357
PMCPMC6390333
OpenAlexW2936556410

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.