Evidence map›Paper›PMID 30808339›Full record

ArticleBMC pregnancy and childbirth2019

Caffeine exposure during pregnancy, small for gestational age birth and neonatal outcome - results from the Norwegian Mother and Child Cohort Study.

Dominika Modzelewska, Rino Bellocco, Anders Elfvin, Anne Lise Brantsæter, Helle Margrete Meltzer, Bo Jacobsson, Verena Sengpiel

Abstract read
In one paragraph

Article in BMC pregnancy and childbirth, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  10. Prenatal caffeine exposure: association with neurodevelopmental outcomes in 9- to 11-year-old children.Journal of child psychology and psychiatry, and allied disciplines · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dominika ModzelewskaInstitute of Clinical Sciences, Department of Obstetrics and Gynecology, University of Gothenburg, Sahlgrenska Academy, SE-416 85, Gothenburg, Sweden. dominika.modzelewska@gu.se.ORCID http://orcid.org/0000-0001-7715-1075
Rino BelloccoDepartment of Statistics and Quantitative Methods, University of Milano-Bicocca, Milan, Italy.
Anders ElfvinDepartment of Pediatrics, The Queen Silvia Children's Hospital, Sahlgrenska University Hospital, Gothenburg, Sweden.
Anne Lise BrantsæterDepartment of Environmental Exposure and Epidemiology, Domain of Infection Control and Environmental Health, Norwegian Institute of Public Health, P.O. Box 4404 Nydalen, NO-0403, Oslo, Norway.
Helle Margrete MeltzerDepartment of Environmental Exposure and Epidemiology, Domain of Infection Control and Environmental Health, Norwegian Institute of Public Health, P.O. Box 4404 Nydalen, NO-0403, Oslo, Norway.
Bo JacobssonInstitute of Clinical Sciences, Department of Obstetrics and Gynecology, University of Gothenburg, Sahlgrenska Academy, SE-416 85, Gothenburg, Sweden.
Verena SengpielDepartment of Obstetrics and Gynecology, Sahlgrenska University Hospital/Östra, SE-416 85, Gothenburg, Sweden.

Funding

Gene-Environment Interactions in an Autism Birth CohortU01NS047537 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LIPKIN, W. IAN · 2003 to 2013
$27.0M
NIEHS NIH HHS N01 ES075558NINDS NIH HHS U01 NS047537
6 · The paper itself

Abstract

backgroundMaternal caffeine intake has repeatedly been linked to babies being born small for gestational age (SGA). SGA babies are known to be at increased risk for adverse neonatal outcomes. The aim of this study was to explore the associations between prenatal caffeine exposure and neonatal health.

methodsThe study is based on 67,569 full-term singleton mother-infant pairs from the Norwegian Mother and Child Cohort Study. Caffeine consumption from different sources was self-reported in gestational week 22. Neonatal compound outcomes, namely (1) morbidity/mortality and (2) neonatal intervention, were created based on the Medical Birth Registry of Norway. Adjusted logistic regression was performed.

resultsCaffeine exposure was associated to SGA (OR = 1.16, 95%CI: 1.10; 1.23) and being born SGA was significantly associated with neonatal health (OR = 3.09, 95%CI: 2.54; 3.78 for morbidity/mortality; OR = 3.94, 95%CI: 3.50; 4.45 for intervention). However, prenatal caffeine exposure was neither associated with neonatal morbidity/mortality (OR = 1.01, 95%CI: 0.96; 1.07) nor neonatal intervention (OR = 1.02, 95%CI: 1.00; 1.05 for a 100 mg caffeine intake increase). Results did not change after additional adjustment for SGA status.

conclusionsModerate prenatal caffeine exposure (< 200 mg/day) does not seem to impair neonatal health, although prenatal caffeine exposure is associated with the child being born SGA and SGA with neonatal health. We suggest diversity in neonatal outcomes of SGA infants according to the underlying cause of low birth weight.

Indexed as

Infant, Small for Gestational AgeAdultBirth WeightCaffeineCohort StudiesFemaleGestational AgeHumansInfant, Low Birth WeightInfant, NewbornInfant, Newborn, DiseasesLogistic ModelsMaternal ExposureNorwayPregnancyPremature BirthCaffeineCaffeineCoffeeNeonatal outcomeNorwegian mother and child cohort studyPregnancySmall for gestational age

Identifiers

PMID30808339
PMCPMC6390347

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.