Observational studyBMC cardiovascular disorders2019
Gender differences in plaque characteristics of nonculprit lesions in patients with coronary artery disease.
Observational study in BMC cardiovascular disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Atherosclerosis after pre-eclampsia: systematic review and meta-analysis.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2026Pooled it
- Sex Differences in Long-term Outcomes Following Coronary Artery Bypass Grafting: A Nationwide Population-Based Propensity Score-Matched Cohort Study.Journal of Korean medical science · 2026Article
- Multimodality OCT, IVUS and FFR evaluation of coronary intermediate grade lesions in women vs. men.Frontiers in cardiovascular medicine · 2023Article
- Near-infrared spectroscopy predicts events in men and women: Results from the Lipid Rich Plaque study.International journal of cardiology. Heart & vasculature · 2022Article
- Trends of Sex Differences in Clinical Outcomes After Myocardial Infarction in the United States.CJC open · 2021Article
- Sex differences in the manifestation and evolution of coronary artery plaques.The international journal of cardiovascular imaging · 2021Article
- Sex differences in coronary plaque changes assessed by serial computed tomography angiography.The international journal of cardiovascular imaging · 2021Article
- Gender differences in coronary artery diameters and survival results after off-pump coronary artery bypass (OPCAB) procedures.Journal of thoracic disease · 2021Article
- Gender-basedJournal of cardiovascular and thoracic research · 2021Article
- Factors influencing left ventricular ejection fraction in patients with coronary microvascular disease and obstructive coronary artery disease.BMC research notes · 2020Observational
- Covid-19 Kills More Men Than Women: An Overview of Possible Reasons.Frontiers in cardiovascular medicine · 2020Review
- The evolving role of coronary computed tomography in understanding sex differences in coronary atherosclerosis.Journal of cardiovascular computed tomographyReview
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough numerous reports suggest sex-related differences in atherosclerosis, limited data describing gender-associated differences in plaque morphology and composition are currently available. The aim of the present study was to compare coronary nonculprit plaque characteristics in women and men with coronary artery disease (CAD) by optical coherence tomography (OCT).
methodsThis was a retrospective study. A total of 187 nonculprit plaques were identified in 103 patients with CAD who underwent OCT imaging of all 3 coronary arteries. These patients included 77 (74.8%) men and 26 (25.2%) women.
resultsFemale patients were significantly older than males (mean age, 70.8 ± 7.3 vs 60.8 ± 9.8 years; P < 0.001) and less likely to be current smokers (P = 0.007). OCT analysis included the presence of lipid-rich plaque, maximum lipid arc, lipid-core length, lipid index (LI), fibrous cap thickness, and the incidence of thin-cap fibroatheroma (TCFA). Nonculprit plaques in men exhibited greater lipid-core length and LI compared with those of women (9.4 ± 4.5 vs. 7.3 ± 4.3 mm, P = 0.024; 1615.1 ± 893.8 vs. 1237.8 ± 859.8, P = 0.035, respectively). In the univariate linear regression model, sex and current smoker were all associated with a larger LI, whereas only use of statin was independent risk factor for a larger LI in multivariate analysis.
conclusionsCoronary nonculprit plaques in male patients with CAD contain larger lipid cores than those of female patients.
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