ArticleClinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Zika and Chikungunya Virus and Risk for Venous Thromboembolism.
Article in Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Elevated D-Dimer Levels Are Associated With Increased Risk of Mortality in Coronavirus Disease 2019: A Systematic Review and Meta-Analysis.Cardiology in reviewPooled it
- Validation of China's 2025 high-risk criteria in RT-PCR-confirmed chikungunya inpatients: a single-centre retrospective cohort.BMC infectious diseases · 2025Article
- Review
- Risk of Venous Thromboembolism in Infectious Diseases: A Literature Review.Pathogens (Basel, Switzerland) · 2025Review
- Unveiling the cardiovascular impact of Zika Virus: Myocardial injury, prothrombotic state, and oxidative stress in immunocompetent mice.PLoS neglected tropical diseases · 2025Article
- Review
- Odds and associated factors for thrombosis development among Lebanese COVID-19 patients: a case-control retrospective study.Journal of pharmaceutical policy and practice · 2024Article
- Article
- Venous thromboembolism in viral diseases: A comprehensive literature review.Health science reports · 2023Article
- Extra-articular Manifestations of Chikungunya.Revista da Sociedade Brasileira de Medicina Tropical · 2023Review
- Clinical Features and Management of COVID-19-Associated Hypercoagulability.Cardiac electrophysiology clinics · 2022Review
- Clinical and cardiovascular characteristics from subjects with in COVID-19 and viral outbreaks.Canadian journal of respiratory therapy : CJRT = Revue canadienne de la therapie respiratoire : RCTR · 2022Article
- Incidence, diagnosis, treatment methods, and outcomes of clinically suspected venous thromboembolic disease in patients with COVID-19 in a quaternary hospital in Brazil.Jornal vascular brasileiro · 2021Article
- Limb ischemia in patients with COVID-19.Jornal vascular brasileiro · 2021Review
- Thromboembolic Complications of SARS-CoV-2 and Metabolic Derangements: Suggestions from Clinical Practice Evidence to Causative Agents.Metabolites · 2021Review
- Deep vein thrombosis in COVID-19 patients in general wards: prevalence and association with clinical and laboratory variables.La Radiologia medica · 2021Article
- Impact of COVID-19 on monitoring of therapeutic unfractionated heparin.Journal of thrombosis and thrombolysis · 2021Article
- Thrombocytopenia in Virus Infections.Journal of clinical medicine · 2021Review
- ACE2: the molecular doorway to SARS-CoV-2.Cell & bioscience · 2020Review
- Case Report: COVID-19 Associated Renal Infarction and Ascending Aortic Thrombosis.The American journal of tropical medicine and hygiene · 2020Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A variety of viral infections are associated with hypercoagulable states and may be linked to the development of deep venous thrombosis and pulmonary embolism. The Zika and Chikungunya viral infections spread through the South and Central American continents, moving to North America in 2016, with severe cases of polyarthralgia, fever, and Guillain-Barré syndrome leading eventually to death. A decreased trend for both infections was reported in the first quarter of 2017. In this article, we report the possible association of venous thromboembolic events associated with Zika infection. After 2 cases of deep venous thrombosis in patients with acute Zika infections, D-dimer levels were measured in 172 consecutive patients who presented to the emergency department of a university hospital in an endemic region of Brazil with either Zika or Chikungunya infections confirmed by polymerase chain reaction tests. D-dimer levels were increased in 19.4% of 31 patients with Zika and in 63.8% of 141 patients with Chikungunya infections. The mechanisms behind this association are yet to be elucidated as well as the potential for venous thromboembolism prevention strategies for in-hospital patients affected by Zika and Chikungunya infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.