ArticleKorean circulation journal2019
Evaluation of Coronary Artery Calcium Progression in Asymptomatic Individuals with an Initial Score of Zero.
Article in Korean circulation journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- Development of coronary artery disease in patients with initially normal coronary arteries in the SCOT-HEART trial.European radiology · 2026Observational
- Associations of Central Adiposity With Subclinical Coronary Calcification and Disease Progression: Meta-Analysis of 68,629 Participants.JACC. Advances · 2026Article
- Relationship Between Aortic Valve and Mitral Annular Calcification With Coronary Artery Calcification in Asymptomatic Individuals: Cross-Sectional and Longitudinal Analyses.Journal of Korean medical science · 2025Article
- Differences in risk factors associated with the initiation and progression of mitral annular calcification in asymptomatic individuals.Scientific reports · 2025Article
- The Role of Serum Calcium Levels in the Progression of Arterial Stiffness: Cross-Sectional and Longitudinal Analyses in a Multicenter Cohort.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- The association of carotid plaque burden and composition and the coronary artery calcium score in intermediate cardiovascular risk patients.The international journal of cardiovascular imaging · 2024Article
- New look at the power of zero coronary artery calcium (CAC) in Asian population: a systemic review and meta-analysis.Cardiovascular diagnosis and therapy · 2024Article
- Higher serum phosphate within the normal range is associated with the development of calcified aortic valve disease.Frontiers in cardiovascular medicine · 2024Article
- Interplay between Risk Factors and Coronary Artery Calcium in Middle-Aged and Elderly Symptomatic Patients.Reviews in cardiovascular medicine · 2023Article
- Utility of coronary artery calcium in refining 10-year ASCVD risk prediction using a Thai CV risk score.Frontiers in cardiovascular medicine · 2023Article
- Visual Ordinal Coronary Artery Calcium Score from Non-Gated Chest CT Predicts Mortality After Severe Chronic Obstructive Pulmonary Disease Exacerbation.International journal of chronic obstructive pulmonary disease · 2023Article
- Glycemic control is independently associated with rapid progression of coronary atherosclerosis in the absence of a baseline coronary plaque burden: a retrospective case-control study from the PARADIGM registry.Cardiovascular diabetology · 2022Article
- Vascular Calcification in Chronic Kidney Disease: Distinct Features of Pathogenesis and Clinical Implication.Korean circulation journal · 2021Review
- Natural course of coronary artery calcium progression in Asian population with an initial score of zero.BMC cardiovascular disorders · 2020Article
- A LASSO-Derived Risk Model for Subclinical CAC Progression in Asian Population With an Initial Score of Zero.Frontiers in cardiovascular medicine · 2020Article
- Which Individuals Could Benefit from Repeat Coronary Calcium Scans among Asymptomatic Korean Adults with a Baseline Coronary Artery Calcium Score of Zero?Korean circulation journal · 2019Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
BACKGROUND AND
objectivesCoronary artery calcium (CAC) scoring in the asymptomatic population can improve cardiovascular risk prediction. We aimed to assess CAC progression and the impact of coronary risk factors on the CAC progression rate in asymptomatic Korean individuals with a baseline CAC score of zero.
methodsThe study population was derived from the Korea Initiatives on Coronary Artery Calcification (KOICA) registry: a retrospective, single ethnicity, multicenter registry of asymptomatic individuals who underwent CAC scoring as a part of a health checkup. Individuals with at least two CAC scores and an initial score of zero were included. CAC progression was defined as [√CAC score (follow-up) - √CAC score (baseline)] ≥2.5. The 10-year atherosclerotic cardiovascular disease (ASCVD) risk was calculated.
resultsAmong 6,268 participants (mean age, 48.0±7.1 years; male, 80.5%), 719 (11.5%) experienced CAC progression during follow-up (median, 109 months; interquartile range, 78-208 months). The CAC progression rate was 0.3%, 1.9%, 4.3%, 8.6%, and 16.7% in years 1-5, respectively. The chance of CAC progression at 5 years was 13.1%, 22.0%, and 27.9% for individuals with a 10-year ASCVD risk of <5%, ≥5% but <7.5%, and ≥7.5%, respectively. A multivariable analysis revealed age, male sex, waist circumference, diabetes, and low-density lipoprotein cholesterol level as independently associated with annualized CAC progression (p<0.001, p=0.017, p=0.025, p=0.032, and p=0.003, respectively).
conclusionsThe probability of CAC progression is very low in Korean individuals with a CAC score of zero. However, the risk of CAC progression increases nonlinearly over time, and increases as the 10-year ASCVD risk increases.
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