Evidence map›Paper›PMID 30808064›Full record

ArticleBritish journal of pharmacology2019

Molecular mechanisms of caffeine-mediated intestinal epithelial ion transports.

Fenglian Zhang, Hanxing Wan, Xin Yang, Jialin He, Cheng Lu, Shiming Yang, Biguang Tuo, Hui Dong

Open access · bronzeAbstract read
In one paragraph

Article in British journal of pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.4field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

  1. Monosodium glutamate-mediated CaPhysiological reports · 2026
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  4. Pharmacological Activation of TRPC6 Channel Prevents Colitis Progression.International journal of molecular sciences · 2024
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  6. Dual ABMC endocrine disorders · 2023
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  9. Capsaicin inhibits intestinal ClThe Journal of biological chemistry · 2022
    Article
  10. CaFrontiers in pharmacology · 2022
    Article
  11. Article
  12. Advances in CaExperimental and therapeutic medicine · 2020
    Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Fenglian ZhangDepartment of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing, China.ORCID 0000-0001-7674-3933
Hanxing WanDepartment of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
Xin YangDepartment of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing, China.ORCID 0000-0003-2019-6568
Jialin HeDepartment of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
Cheng LuDepartment of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
Shiming YangDepartment of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
Biguang TuoDepartment of Gastroenterology, Affiliated Hospital, Zunyi Medical College, and Digestive Disease Institute of Guizhou Province, Zunyi, China.
Hui DongDepartment of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
Army Medical University · CNAffiliated Hospital of Zunyi Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeAs little is known about the effect of caffeine, one of the most widely consumed substances worldwide, on intestinal function, we aimed to study its action on intestinal anion secretion and the underlying molecular mechanisms. EXPERIMENTAL APPROACH: Anion secretion and channel expression were examined in mouse duodenal epithelium by Ussing chambers and immunocytochemistry. Ca KEY

resultsCaffeine (10 mM) markedly increased mouse duodenal short-circuit current (I CONCLUSIONS AND IMPLICATIONS: Caffeine stimulated intestinal anion secretion mainly through the RyR/Orai1/Ca

Indexed as

AnimalsBicarbonatesCaffeineCalciumCalcium SignalingCell LineChloridesCyclic AMPDogsDuodenumHumansIntestinal MucosaMaleMice, Inbred C57BLORAI1 ProteinRyanodine Receptor Calcium Release ChannelBicarbonatesCaffeineCalciumChloridesCyclic AMPORAI1 ProteinRyanodine Receptor Calcium Release Channel

Identifiers

PMID30808064
PMCPMC6514291
OpenAlexW2915569838

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.