Evidence map›Paper›PMID 30807904›Full record

ReviewCell calcium2019

Numbers count: How STIM and Orai stoichiometry affect store-operated calcium entry.

Michelle Yen, Richard S Lewis

Open access · greenAbstract readReview
In one paragraph

Review in Cell calcium, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. The Important Role of Ion Transport System in Cervical Cancer.International journal of molecular sciences · 2021
    Review
  13. Review
  14. Receptor-Dependent and Independent Regulation of Voltage-Gated CaInternational journal of molecular sciences · 2021
    Review
  15. Review
  16. The store-operated CaProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  17. Physiological and Pathological Relevance of Selective and Nonselective CaAdvances in experimental medicine and biology · 2021
    Article
  18. Altered CaInternational journal of molecular sciences · 2020
    Review
  19. Article
  20. Orai channels: key players in CaCurrent opinion in physiology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Michelle YenDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, 94305, United States.
Richard S LewisDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, 94305, United States. Electronic address: rslewis@stanford.edu.
Stanford University · US

Funding

MOLECULAR &CELLULAR IMMUNOBIOLOGYT32AI007290 · NIAID · STANFORD UNIVERSITY · PI Sean Curtis Bendall, Olivia M Martinez · 1985 to 2026
$27.0M
Ion Channels and Signaling Mechanisms in T LymphocytesR37GM045374 · NIGMS · STANFORD UNIVERSITY · PI LEWIS, RICHARD S · 2012 to 2021
$6.2M
NIAID NIH HHS T32 AI007290NIGMS NIH HHS R37 GM045374
6 · The paper itself

Abstract

Substantial progress has been made in the past several years in establishing the stoichiometries of STIM and Orai proteins and understanding their influence on store-operated calcium entry. Depletion of ER Ca

Indexed as

CalciumCalcium Release Activated Calcium ChannelsCell MembraneEndoplasmic ReticulumHumansNeoplasm ProteinsORAI1 ProteinStromal Interaction Molecule 1CalciumCalcium Release Activated Calcium ChannelsNeoplasm ProteinsORAI1 ProteinORAI1 protein, humanSTIM1 protein, humanStromal Interaction Molecule 1ConcatemerCRAC channelOraiSTIMStoichiometryStore-operated calcium entry

Identifiers

PMID30807904
PMCPMC6461473
OpenAlexW2913681907

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.