Evidence map›Paper›PMID 30807757›Full record

ArticleToxicology and applied pharmacology2019

Suppression of CpG-ODN-mediated IFNα and TNFα response in human plasmacytoid dendritic cells (pDC) by cannabinoid receptor 2 (CB2)-specific agonists.

Joseph E Henriquez, Robert B Crawford, Norbert E Kaminski

Open access · greenAbstract readComparative Study
In one paragraph

Article in Toxicology and applied pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.4field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. AMolecules (Basel, Switzerland) · 2023
    Article
  3. Review
  4. Review
  5. Article
  6. Expression and Functions of the CBFrontiers in pharmacology · 2022
    Article
  7. Review
  8. Review
  9. Review
  10. Immune Responses Regulated by Cannabidiol.Cannabis and cannabinoid research · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Joseph E HenriquezDepartment of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA; Institute for Integrative Toxicology, Michigan State University, East Lansing, MI 48824, USA.
Robert B CrawfordInstitute for Integrative Toxicology, Michigan State University, East Lansing, MI 48824, USA.
Norbert E KaminskiDepartment of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA; Institute for Integrative Toxicology, Michigan State University, East Lansing, MI 48824, USA. Electronic address: kamins11@msu.edu.
Michigan State University · US

Funding

MULTIDISCIPLINARY TRAINING IN ENVIRONMENTAL TOXICOLOGYT32ES007255 · NIEHS · MICHIGAN STATE UNIVERSITY · PI JOHN J LAPRES · 1989 to 2026
$9.3M
THC impairment of CD4/CD8 T cell-mediated host resistance to HIV and influenzaR01DA007908 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI KAMINSKI, NORBERT E · 1992 to 2013
$3.0M
Cannabinoids Modulate Immune Cell-provoked Astrocyte Functions to Suppress HIV-Associated Neuroinflammatory ResponsesR01DA047180 · NIDA · MICHIGAN STATE UNIVERSITY · PI KAMINSKI, NORBERT E · 2018 to 2023
$2.4M
NIDA NIH HHS R01 DA007908NIDA NIH HHS R01 DA047180NIEHS NIH HHS T32 ES007255
6 · The paper itself

Abstract

Plasmacytoid dendritic cells (pDC) compose 0.2-0.5% of circulating leukocytes but play a significant role in mounting host immune responses. Elevated and chronic activation of pDC are implicated in autoimmune disease like systemic lupus erythematosus and rheumatoid arthritis. Δ

Indexed as

Anti-Inflammatory AgentsCannabinoid Receptor AgonistsCannabinoidsCells, CulturedDendritic CellsHumansIndolesInterferon-gammaOligodeoxyribonucleotidesPhosphorylationReceptor, Cannabinoid, CB2Signal TransductionTumor Necrosis Factor-alpha1,1-dimethylbutyl-1-deoxy-Delta(9)-THCAnti-Inflammatory AgentsCannabinoid Receptor AgonistsCannabinoidsCNR2 protein, humanCPG-oligonucleotideIFNG protein, humanIndolesInterferon-gammaJHW 015OligodeoxyribonucleotidesReceptor, Cannabinoid, CB2TNF protein, humanTumor Necrosis Factor-alphaCannabinoidsInterferon αPlasmacytoid dendritic cellsToll-like receptorsTumor necrosis factor αΔ9-Tetrahydrocannabinol

Identifiers

PMID30807757
PMCPMC7243911
OpenAlexW2917055859

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.