ArticlePloS one2019
The first isolation of Clostridium difficile RT078/ST11 from pigs in China.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Comparison of Phenotypic and Genotypic Antimicrobial Resistances in BovineAntibiotics (Basel, Switzerland) · 2026Article
- Article
- Community-AcquiredInternational journal of molecular sciences · 2025Review
- Genomic analysis of a novel ST11(PR34365)Open life sciences · 2025Article
- Antimicrobial resistance ofOne health (Amsterdam, Netherlands) · 2024Article
- Genomic epidemiology ofEmerging microbes & infections · 2024Article
- Article
- Characterization of Food ChainMicroorganisms · 2023Article
- Article
- Characterization of community-acquiredFrontiers in microbiology · 2023Article
- Detection and Genomic Characterisation ofPathogens (Basel, Switzerland) · 2022Article
- Isolation, molecular typing and antimicrobial resistance ofFrontiers in veterinary science · 2022Article
- Raw Animal Meats as Potential Sources ofFood science of animal resources · 2021Article
- The molecular characters and antibiotic resistance of Clostridioides difficile from economic animals in China.BMC microbiology · 2020Article
- Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2020Review
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
We investigated the molecular characteristics and antimicrobial susceptibility of Clostridium difficile isolated from animals in China. We obtained 538 rectal swabs from pigs, chickens and ducks in 5 provinces during 2015 and 2016. C. difficile isolates were characterized by detection of toxin genes, multilocus sequence typing and ribotyping. And antimicrobial susceptibility testing was performed using the agar dilution method. Out of 538 samples, 44 (8.2%) were C. difficile positive with high prevalence in pigs (n = 31). Among these, 39 (88.6%) were toxigenic including 14 (31.8%) that were A+B+CDT+ and 13 (29.5%) A+B+. The remaining 12 (27.3%) were A-B+. We identified 7 ST types and 6 PCR ribotypes. The most predominant type was ST11/RT078 with toxin profile A+B+CDT+ and all were isolated from piglets with diarrhea. ST109 isolates possessed two different toxigenic profiles (A-B-CDT- and A-B+CDT-) and although it was not the most prevalent sequence type, but it was widely distributed between chickens, ducks and pigs in the 5 provinces. All C. difficile isolates were fully susceptible to vancomycin, metronidazole, fidaxomicin, amoxicillin/clavulanate and meropenem but retained resistance to 4 or 5 of the remaining antibiotics, especially cefotaxime, tetracycline, ciprofloxacin, cefoxitin. The RT078/ST11 isolates were simultaneously resistant to cefotaxime, tetracycline, cefoxitin, ciprofloxacin and imipenem. This is the first report of the molecular epidemiology of C. difficile isolated from food animals in China. We identified the epidemic strain RT078/ST11 as the predominate isolate among the animals we screened in our study.
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