ReviewJournal of microbiology (Seoul, Korea)2019
Ribosome dependence of persister cell formation and resuscitation.
Review in Journal of microbiology (Seoul, Korea), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- From dividing to dormant: embracing the full activity spectrum for environmental microorganisms.Microbiology and molecular biology reviews : MMBR · 2026Review
- Single-cell heterogeneity in ribosome levels and protein synthesis during nutrient starvation is driven by cAMP signaling.Science advances · 2026Article
- From Dormancy to Viability: The Resuscitation Processes of Viable but Non-Culturable Bacteria-A Systematic Review.Microorganisms · 2026Review
- Bistability in type I toxin-antitoxin systems may lead to stress-induced persister formation.NPJ systems biology and applications · 2025Article
- Glucose Supplementation Enhances the Bactericidal Effect of Penicillin and Gentamicin onAntibiotics (Basel, Switzerland) · 2025Article
- Cyclic di-GMP as an antitoxin regulates bacterial genome stability and antibiotic persistence in biofilms.eLife · 2024Article
- Characterization ofMicroorganisms · 2024Article
- Unveiling the critical roles of cellular metabolism suppression in antibiotic tolerance.npj antimicrobials and resistance · 2024Article
- Toxin/antitoxin systems induce persistence and work in concert with restriction/modification systems to inhibit phage.Microbiology spectrum · 2024Article
- Molecular physiological characterization of the dynamics of persister formation inAntimicrobial agents and chemotherapy · 2024Article
- Persister Cell Formation and ElevatedMicroorganisms · 2023Article
- Proteomic analysis of the initial wake up of vibrio splendidus persister cells.World journal of microbiology & biotechnology · 2023Article
- Overexpression of a DNA Methyltransferase Increases Persister Cell Formation in Acinetobacter baumannii.Microbiology spectrum · 2022Article
- Feasibility of novel approaches to detect viableFrontiers in medicine · 2022Review
- Exposure to stressors and antimicrobials induces cell-autonomous ultrastructural heterogeneity of an intracellular bacterial pathogen.Frontiers in cellular and infection microbiology · 2022Article
- Cellular Self-Digestion and Persistence in Bacteria.Microorganisms · 2021Review
- Review
- Magnesium Hydroxide Nanoparticles Kill Exponentially Growing and PersisterNanomaterials (Basel, Switzerland) · 2021Article
- Antibiotic tolerance is associated with a broad and complex transcriptional response in E. coli.Scientific reports · 2021Article
- Contribution of Drugs Interfering with Protein and Cell Wall Synthesis to the Persistence ofInternational journal of molecular sciences · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since most bacterial cells are starving, they must enter a resting stage. Persister is the term used for metabolically-dormant cells that are not spores, and these cells arise from stress such as that from antibiotics as well as that from starvation. Because of their lack of metabolism, persister cells survive exposure to multiple stresses without undergoing genetic change; i.e., they have no inherited phenotype and behave as wild-type cells once the stress is removed and nutrients are presented. In contrast, mutations allow resistant bacteria to grow in the presence of antibiotics and slow growth allows tolerant cells to withstand higher concentrations of antibiotics; hence, there are three closely-related phenotypes: persistent, resistant, and tolerant. In addition, since dormancy is so prevalent, persister cells must have a means for resuscitating (since so many cells should obtain this resting state). In this review, we focus on what is known about the formation and resuscitation of persister cells.
Indexed as
Identifiers
30806978What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.