Evidence map›Paper›PMID 30806837›Full record

ReviewCurrent diabetes reports2019

Triglycerides: Emerging Targets in Diabetes Care? Review of Moderate Hypertriglyceridemia in Diabetes.

Anastasia-Stefania Alexopoulos, Ali Qamar, Kathryn Hutchins, Matthew J Crowley, Bryan C Batch, John R Guyton

Abstract readReview
In one paragraph

Review in Current diabetes reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 63 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Anastasia-Stefania AlexopoulosDepartment of Medicine, Division of Endocrinology, Duke University Medical Center, Durham, NC, USA. asa61@duke.edu.
Ali QamarDepartment of Medicine, Division of Endocrinology, Duke University Medical Center, Durham, NC, USA.
Kathryn HutchinsDepartment of Medicine, Division of Endocrinology, Duke University Medical Center, Durham, NC, USA.
Matthew J CrowleyDepartment of Medicine, Division of Endocrinology, Duke University Medical Center, Durham, NC, USA.
Bryan C BatchDepartment of Medicine, Division of Endocrinology, Duke University Medical Center, Durham, NC, USA.
John R GuytonDepartment of Medicine, Division of Endocrinology, Duke University Medical Center, Durham, NC, USA.
Duke Medical Center · USDurham VA Medical Center · US

Funding

Endocrinology and Metabolism Training ProgramT32DK007012 · NIDDK · DUKE UNIVERSITY · PI DAVID A. D'ALESSIO · 1986 to 2026
$6.8M
NIDDK NIH HHS T32 DK007012
6 · The paper itself

Abstract

purpose of reviewModerate hypertriglyceridemia is exceedingly common in diabetes, and there is growing evidence that it contributes to residual cardiovascular risk in statin-optimized patients. Major fibrate trials yielded inconclusive results regarding the cardiovascular benefit of lowering triglycerides, although there was a signal for improvement among patients with high triglycerides and low high-density lipoprotein (HDL)-the "diabetic dyslipidemia" phenotype. Until recently, no trials have examined a priori the impact of triglyceride lowering in patients with diabetic dyslipidemia, who are likely among the highest cardiovascular-risk patients. RECENT

findingsIn the recent REDUCE IT trial, omega-3 fatty acid icosapent ethyl demonstrated efficacy in lowering cardiovascular events in patients with high triglycerides, low HDL, and statin-optimized low-density lipoprotein (LDL). The ongoing PROMINENT trial is examining the impact of pemafibrate in a similar patient population. Emerging evidence suggests that lowering triglycerides may reduce residual cardiovascular risk, especially in high-risk patients with diabetic dyslipidemia.

Indexed as

Cardiovascular DiseasesClinical Trials as TopicDiabetes ComplicationsHumansHyperlipidemiasHypertriglyceridemiaHypoglycemic AgentsHypolipidemic AgentsRisk Reduction BehaviorTriglyceridesHypoglycemic AgentsHypolipidemic AgentsTriglyceridesDiabetic dyslipidemiaHypertriglyceridemiaMedicationsType 2 diabetes

Identifiers

PMID30806837
PMCPMC6664805
OpenAlexW2916891528

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.