ArticleInternational archives of occupational and environmental health2019
Association of organic solvents and occupational noise on hearing loss and tinnitus among adults in the U.S., 1999-2004.
Article in International archives of occupational and environmental health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06729632 (Non-Invasive System to Deliver Therapeutic Hypothermia for Protection Against Noise-Induced Hearing Loss), which is not on this map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Non-Invasive System to Deliver Therapeutic Hypothermia for Protection Against Noise-Induced Hearing Loss
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between diabetes mellitus and tinnitus: A meta-analysis.Biomolecules & biomedicine · 2025Pooled it
- Combined effects of xylene and noise exposure at realistic low levels on hearing impairment: a cross-sectional study in China.Preventive medicine reports · 2026Article
- Genetic and Environmental Factors Shaping Hearing Loss: Xenobiotics, Mechanisms and Translational Perspectives.Journal of xenobiotics · 2026Review
- Nephroprotective Potential of Olea europaea Leaf Extract Against Combined Noise and Toluene-Induced Oxidative and Histopathological Renal Injuries in Wistar Rats.Chemistry & biodiversity · 2026Article
- Detailed hazard assessment of ethylbenzene to establish an indoor air quality guideline in Japan.Environmental health and preventive medicine · 2025Article
- Which Environmental Pollutants Are Toxic to Our Ears?-Evidence of the Ototoxicity of Common Substances.Toxics · 2024Review
- Higher exposure to 1,3-butadiene is associated with more severe hearing loss.Scientific reports · 2024Article
- Hearing Loss and UrinaryToxics · 2024Article
- Association between blood volatile organic aromatic compound concentrations and hearing loss in US adults.BMC public health · 2024Article
- Development, Insults and Predisposing Factors of the Brain's Predictive Coding System to Chronic Perceptual Disorders-A Life-Course Examination.Brain sciences · 2024Article
- Association of mixed polycyclic aromatic hydrocarbons exposure with hearing loss and the mediating role of blood cell markers of inflammation in U.S. adults.Frontiers in public health · 2024Article
- Environmental Exposures and Hearing Loss.International journal of environmental research and public health · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
purposeExposure to organic solvents and noise may be causal agents in the development of hearing loss and tinnitus. The objectives of the present study were to examine the association of organic solvents with hearing loss and tinnitus and to assess the interaction of organic solvent and occupational noise exposure on hearing loss and tinnitus.
methodsA secondary data analysis of data from the National Health and Nutrition Examination Survey and Occupational Information Network (O*NET) among a study population ranging from 1085 to 2471 study participants from 1999 to 2004. Multiple multivariate logistic regression models were used to assess the associations of individual organic solvent exposures as measured by blood biomarkers (1,4-dichlorobenzene, benzene, ethylbenzene, styrene, toluene, o-xylene, and m-/p-xylene) with self-reported hearing loss, audiometrically assessed hearing loss, and self-reported tinnitus. Models were adjusted for age, gender, race/ethnicity, diabetes, non-occupational noise exposure, smoking, and income. Organic solvents found to be statistically significantly associated with the outcome after adjusting for covariates were tested for interaction with occupational noise exposure.
resultsSolvent exposure was not statistically significantly associated with self-reported tinnitus. Benzene (OR 1.43, 95% CI 1.15-1.78), ethylbenzene (OR 1.24, 95% CI 1.02-1.50), and toluene (OR 1.27, 95% CI 1.06-1.52) concentrations were statistically significantly associated with increased adjusted odds of high-frequency hearing loss. No statistically significant interaction was observed between these solvents and occupational noise on high-frequency hearing loss.
conclusionsWe found no evidence of an association between organic solvents and tinnitus; however, there was evidence of an association between organic solvent exposure and prevalence of high-frequency hearing loss.
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