Evidence map›Paper›PMID 30806771›Full record

ArticleEuropean archives of psychiatry and clinical neuroscience2020

Binding varicella zoster virus: an underestimated facet of insulin-degrading enzyme´s implication for Alzheimer´s disease pathology?

Hans-Gert Bernstein, Gerburg Keilhoff, Henrik Dobrowolny, Johann Steiner

Abstract readLetter
PubMed Publisher
In one paragraph

Article in European archives of psychiatry and clinical neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. The association between varicella zoster virus and dementia: a systematic review and meta-analysis of observational studies.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Pooled it
  3. Pooled it
  4. Review
  5. Article
  6. Review
  7. Viruses · 2024
    Review
  8. Review
  9. Frontiers in microbiology · 2022
    Review
  10. Article
  11. Some Candidate Drugs for Pharmacotherapy of Alzheimer's Disease.Pharmaceuticals (Basel, Switzerland) · 2021
    Review
  12. Review
  13. Antibiotics, gut microbiota, and Alzheimer's disease.Journal of neuroinflammation · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hans-Gert BernsteinDepartment of Psychiatry and Psychotherapy, Medical Faculty, University of Magdeburg, 39120, Magdeburg, Germany. Hans-Gert.Bernstein@med.ovgu.de.
Gerburg KeilhoffMedical Faculty, Institute of Biochemistry and Cell Biology, University of Magdeburg, 39120, Magdeburg, Germany.
Henrik DobrowolnyDepartment of Psychiatry and Psychotherapy, Medical Faculty, University of Magdeburg, 39120, Magdeburg, Germany.
Johann SteinerDepartment of Psychiatry and Psychotherapy, Medical Faculty, University of Magdeburg, 39120, Magdeburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We shortly discuss a possible contribution of insulin-degrading enzyme to Alzheimer´s disease pathology by binding varicella zoster virus glycoprotein E, which increases the infectivity and cell-cell spread of the virus.

Indexed as

AgedAged, 80 and overAlzheimer DiseaseHerpesvirus 3, HumanHumansInsulysinViral Envelope Proteinsglycoprotein E, varicella-zoster virusInsulysinViral Envelope Proteins

Identifiers

PMID30806771

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.