Evidence map›Paper›PMID 30806624›Full record

ArticleeLife2019

Long-term balancing selection drives evolution of immunity genes in

Daniel Koenig, Jörg Hagmann, Rachel Li, Felix Bemm, Tanja Slotte, Barbara Neuffer, Stephen I Wright, Detlef Weigel

Abstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed.

  1. Balanced polymorphism in a floral transcription factor underlies the ancient rhythm of daily sex alternation in avocado.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Population Genetic Study ofEcology and evolution · 2026
    Article
  7. Article
  8. A century of theories of balancing selection.Biological reviews of the Cambridge Philosophical Society · 2026
    Review
  9. Parasite defense covaries with reproductive timing, not with resistance.bioRxiv : the preprint server for biology · 2026
    Article
  10. Article
  11. Polarising SNPs Without Outgroup.Molecular ecology resources · 2026
    Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. bioRxiv : the preprint server for biology · 2025
    Article
  17. Review
  18. Article
  19. Article
  20. Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Daniel KoenigDepartment of Molecular Biology, Max Planck Institute for Developmental Biology, Tübingen, Germany.ORCID 0000-0002-1037-5346
Jörg HagmannDepartment of Molecular Biology, Max Planck Institute for Developmental Biology, Tübingen, Germany.
Rachel LiDepartment of Molecular Biology, Max Planck Institute for Developmental Biology, Tübingen, Germany.ORCID 0000-0002-8112-4237
Felix BemmDepartment of Molecular Biology, Max Planck Institute for Developmental Biology, Tübingen, Germany.
Tanja SlotteDepartment of Ecology,Environment, and Plant Sciences, Stockholm University, Stockholm, Sweden.
Barbara NeufferDepartment of Biology, University of Osnabrück, Osnabrück, Germany.
Stephen I WrightDepartment of Ecology and Evolutionary Biology, University of Toronto, Toronto, Canada.ORCID 0000-0001-9973-9697
Detlef WeigelDepartment of Molecular Biology, Max Planck Institute for Developmental Biology, Tübingen, Germany.ORCID 0000-0002-2114-7963

Funding

Deutsche Forschungsgemeinschaft WE 2897/4-2European Research Council IMMUNEMESISHuman Frontier Science Program LT000783/2010-LMax-Planck-Gesellschaft Open-access funding
6 · The paper itself

Abstract

Genetic drift is expected to remove polymorphism from populations over long periods of time, with the rate of polymorphism loss being accelerated when species experience strong reductions in population size. Adaptive forces that maintain genetic variation in populations, or balancing selection, might counteract this process. To understand the extent to which natural selection can drive the retention of genetic diversity, we document genomic variability after two parallel species-wide bottlenecks in the genus

Indexed as

Adaptation, BiologicalEvolution, MolecularGenes, PlantSelection, GeneticCapsellaGenetic Variationbalancing selectionbottleneckdisease resistanceevolutionary biologygeneticsgenomicsimmunityNB-LRRselfing

Identifiers

PMID30806624
PMCPMC6426441

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.