Evidence map›Paper›PMID 30806491›Full record

ArticleJournal of veterinary internal medicine2019

ACVIM consensus statement on the diagnosis of immune-mediated hemolytic anemia in dogs and cats.

Oliver A Garden, Linda Kidd, Angela M Mexas, Yu-Mei Chang, Unity Jeffery, Shauna L Blois, Jonathan E Fogle, Amy L MacNeill, George Lubas, Adam Birkenheuer and 12 more

Open access · goldAbstract readConsensus Statement
In one paragraph

Article in Journal of veterinary internal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 4 pooled it
13.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 4 syntheses or guidelines pooled it, 193 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Sepsis in Dogs and Cats-Consensus Definition and Clinical Criteria.Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)
    Pooled it
  4. Septic Shock and Prognosis in Dogs and Cats With Sepsis-Consensus Definition and Clinical Criteria.Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)
    Pooled it
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  12. Clinicopathological abnormalities and outcome of acuteCurrent research in parasitology & vector-borne diseases · 2026
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28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 19 institutions in 5 countries.

Oliver A GardenSchool of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.ORCID https://orcid.org/0000-0002-4133-9487
Linda KiddCollege of Veterinary Medicine, Western University of Health Sciences, Pomona, California.ORCID https://orcid.org/0000-0002-2464-0796
Angela M MexasCollege of Veterinary Medicine, Midwestern University, Downers Grove, Illinois.
Yu-Mei ChangRoyal Veterinary College, University of London, London, United Kingdom.ORCID https://orcid.org/0000-0001-6388-9626
Unity JefferyCollege of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, Texas.ORCID https://orcid.org/0000-0002-0495-2741
Shauna L BloisOntario Veterinary College, University of Guelph, Guelph, Ontario, Canada.ORCID https://orcid.org/0000-0002-4148-4617
Jonathan E FogleCollege of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina.
Amy L MacNeillCollege of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado.ORCID https://orcid.org/0000-0002-1690-3787
George LubasDepartment of Veterinary Sciences, University of Pisa, Pisa, Italy.ORCID https://orcid.org/0000-0002-9430-1060
Adam BirkenheuerCollege of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina.ORCID https://orcid.org/0000-0002-2617-2252
Simona BuoncompagniInternal Medicine Service, Central Oklahoma Veterinary Specialists, Oklahoma City, Oklahoma.
Julien R S DandrieuxFaculty of Veterinary and Agricultural Sciences, Melbourne Veterinary School, University of Melbourne, Melbourne, Australia.ORCID https://orcid.org/0000-0001-6308-8749
Antonio Di LoriaDepartment of Veterinary Medicine and Animal Production, University of Napoli Federico II, Napoli, Italy.
Claire L FellmanCummings School of Veterinary Medicine, Tufts University, Massachusetts.
Barbara GlanemannRoyal Veterinary College, University of London, London, United Kingdom.ORCID https://orcid.org/0000-0003-4830-7610
Robert GoggsCollege of Veterinary Medicine, Cornell University, Ithaca, New York.ORCID https://orcid.org/0000-0001-7446-6987
Jennifer L GranickCollege of Veterinary Medicine, University of Minnesota, Saint Paul, Minnesota.ORCID https://orcid.org/0000-0001-8330-3848
Dana N LeVineDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa.ORCID https://orcid.org/0000-0002-1089-5640
Claire R SharpCollege of Veterinary Medicine, School of Veterinary and Life Sciences, Murdoch University, Perth, Australia.
Saralyn Smith-CarrCollege of Veterinary Medicine, Auburn University, Auburn, Alabama.
James W SwannKennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom.ORCID https://orcid.org/0000-0001-7988-9997
Balazs SzladovitsRoyal Veterinary College, University of London, London, United Kingdom.ORCID https://orcid.org/0000-0002-1926-3455
University of London · GBNorth Carolina State University · USAuburn University · USColorado State University · USCornell University · USIowa State University · USMidwestern University · USMurdoch University · AUOklahoma Cancer Specialists and Research Institute · USTexas A&M University · USThe University of Melbourne · AUTufts University · USUniversity of Guelph · CAUniversity of Minnesota · USUniversity of Naples Federico II · ITUniversity of Oxford · GBUniversity of Pennsylvania · USUniversity of Pisa · ITWestern University of Health Sciences · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune-mediated hemolytic anemia (IMHA) is an important cause of morbidity and mortality in dogs. IMHA also occurs in cats, although less commonly. IMHA is considered secondary when it can be attributed to an underlying disease, and as primary (idiopathic) if no cause is found. Eliminating diseases that cause IMHA may attenuate or stop immune-mediated erythrocyte destruction, and adverse consequences of long-term immunosuppressive treatment can be avoided. Infections, cancer, drugs, vaccines, and inflammatory processes may be underlying causes of IMHA. Evidence for these comorbidities has not been systematically evaluated, rendering evidence-based decisions difficult. We identified and extracted data from studies published in the veterinary literature and developed a novel tool for evaluation of evidence quality, using it to assess study design, diagnostic criteria for IMHA, comorbidities, and causality. Succinct evidence summary statements were written, along with screening recommendations. Statements were refined by conducting 3 iterations of Delphi review with panel and task force members. Commentary was solicited from several professional bodies to maximize clinical applicability before the recommendations were submitted. The resulting document is intended to provide clinical guidelines for diagnosis of, and underlying disease screening for, IMHA in dogs and cats. These should be implemented with consideration of animal, owner, and geographical factors.

Indexed as

ConsensusAnemia, Hemolytic, AutoimmuneAnimalsCat DiseasesCatsComorbidityDog DiseasesDogsSocieties, VeterinarycomorbidityDelphi surveydirect antiglobulin testerythrocyteevidenceflow cytometryhemolysisiceberg modelspherocyteveterinary and comparative clinical immunology society

Identifiers

PMID30806491
PMCPMC6430921
OpenAlexW2916933869

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.