ArticleeLife2019
Adaptation of olfactory receptor abundances for efficient coding.
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Article
- Undoing of firing rate adaptation enables invariant population codes.Science advances · 2026Article
- Convergent motifs of early olfactory processing are recapitulated by layer-wise efficient coding.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- How the olfactory bulb maintains stable odor manifolds amid adaptation and representational drift.bioRxiv : the preprint server for biology · 2026Article
- When noncanonical olfaction is optimal.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Convergent motifs of early olfactory processing are recapitulated by layer-wise efficient coding.bioRxiv : the preprint server for biology · 2025Article
- Genomic and phenotypic evidence support visual and olfactory shifts in primate evolution.Nature ecology & evolution · 2025Article
- Trading Place for Space: Increasing Location Resolution Reduces Contextual Capacity in Hippocampal Codes.bioRxiv : the preprint server for biology · 2025Article
- The primacy model and the structure of olfactory space.PLoS computational biology · 2024Article
- Slow and steady: auditory features for discriminating animal vocalizations.bioRxiv : the preprint server for biology · 2024Article
- Neural Circuits for Fast Poisson Compressed Sensing in the Olfactory Bulb.bioRxiv : the preprint server for biology · 2023Article
- Neural Circuits for Fast Poisson Compressed Sensing in the Olfactory Bulb.Advances in neural information processing systems · 2023Article
- Efficient information coding and degeneracy in the nervous system.Current opinion in neurobiology · 2022Review
- Efficient processing of natural scenes in visual cortex.Frontiers in cellular neuroscience · 2022Review
- Binding site identification of G protein-coupled receptors through a 3D Zernike polynomials-based method: application to C. elegans olfactory receptors.Journal of computer-aided molecular design · 2022Article
- Article
- Rat sensitivity to multipoint statistics is predicted by efficient coding of natural scenes.eLife · 2021Article
- Dynamical self-organization and efficient representation of space by grid cells.Current opinion in neurobiology · 2021Review
- Cortical feedback and gating in odor discrimination and generalization.PLoS computational biology · 2021Article
- What the odor is not: Estimation by elimination.Physical review. E · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Olfactory receptor usage is highly heterogeneous, with some receptor types being orders of magnitude more abundant than others. We propose an explanation for this striking fact: the receptor distribution is tuned to maximally represent information about the olfactory environment in a regime of efficient coding that is sensitive to the global context of correlated sensor responses. This model predicts that in mammals, where olfactory sensory neurons are replaced regularly, receptor abundances should continuously adapt to odor statistics. Experimentally, increased exposure to odorants leads variously, but reproducibly, to increased, decreased, or unchanged abundances of different activated receptors. We demonstrate that this diversity of effects is required for efficient coding when sensors are broadly correlated, and provide an algorithm for predicting which olfactory receptors should increase or decrease in abundance following specific environmental changes. Finally, we give simple dynamical rules for neural birth and death processes that might underlie this adaptation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.