ArticleJournal of the International Neuropsychological Society : JINS2019
Apathy Is Related to Cognitive Control and Striatum Volumes in Prodromal Huntington's Disease.
Article in Journal of the International Neuropsychological Society : JINS, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- Improving the Clinical Diagnostic Criteria for Genetically Confirmed Adult-Onset Huntington Disease: Considering Nonmotor Presentations.Neurology. Clinical practice · 2025Article
- Apathy and Functional Status in Early-Stage Huntington's Disease.The Journal of neuropsychiatry and clinical neurosciences · 2025Article
- [Psychiatric symptoms of Huntington's disease].Der Nervenarzt · 2024Review
- Understanding the implications of a complete case analysis for regression models with a right-censored covariate.The American statistician · 2024Article
- Caudate volume and symptoms of apathy in older adults with multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2023Article
- Cognitive and behavioral associated changes in manifest Huntington disease: A retrospective cross-sectional study.Brain and behavior · 2021Article
- Insights into the Pathophysiology of Psychiatric Symptoms in Central Nervous System Disorders: Implications for Early and Differential Diagnosis.International journal of molecular sciences · 2021Review
- Dissociable Motivational Deficits in Pre-manifest Huntington's Disease.Cell reports. Medicine · 2020Article
- White matter cortico-striatal tracts predict apathy subtypes in Huntington's disease.NeuroImage. Clinical · 2019Article
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Authors and funding
9 authors at 3 institutions in 1 country.
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Abstract
objectivesApathy is a debilitating symptom of Huntington's disease (HD) and manifests before motor diagnosis, making it an excellent therapeutic target in the preclinical phase of Huntington's disease (prHD). HD is a neurological genetic disorder characterized by cognitive and motor impairment, and psychiatric abnormalities. Apathy is not well characterized within the prHD. In previous literature, damage to the caudate and putamen has been correlated with increased apathy in other neurodegenerative and movement disorders. The objective of this study was to determine whether apathy severity in individuals with prHD is related to striatum volumes and cognitive control. We hypothesized that, within prHD individuals, striatum volumes and cognitive control scores would be related to apathy.
methodsWe constructed linear mixed models to analyze striatum volumes and cognitive control, a composite measure that includes tasks assessing with apathy scores from 797 prHD participants. The outcome variable for each model was apathy, and the independent variables for the four separate models were caudate volume, putamen volume, cognitive control score, and motor symptom score. We also included depression as a covariate to ensure that our results were not solely related to mood.
resultsCaudate and putamen volumes, as well as measures of cognitive control, were significantly related to apathy scores even after controlling for depression.
conclusionsThe behavioral apathy expressed by these individuals was related to regions of the brain commonly associated with isolated apathy, and not a direct result of mood symptoms. (JINS, 2019, 25, 462-469).
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