ArticleBrain and behavior2019
A resting-state study of volumetric and functional connectivity of the habenular nucleus in treatment-resistant depression patients.
Article in Brain and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Investigation of habenula volume in mood disorders: A meta-analytic study.Psychological medicine · 2026Pooled it
- The habenula in mood disorders: A systematic review of human studies.Molecular psychiatry · 2025Pooled it
- Seed-based resting-state connectivity as a neurosignature in fibromyalgia and depression: a narrative systematic review.Frontiers in human neuroscience · 2025Pooled it
- Significant heterogeneity in structural asymmetry of the habenula in the human brain: A systematic review and meta-analysis.Human brain mapping · 2023Pooled it
- Reproducibility of automated habenula segmentation via deep learning in major depressive disorder and normal controls with 7 Tesla MRI.Scientific reports · 2021Trial
- Habenula Connectivity and Intravenous Ketamine in Treatment-Resistant Depression.The international journal of neuropsychopharmacology · 2021Trial
- Exploring the Causal Association between Erectile Dysfunction and Brain Cortical Structure: Insight from a Bidirectional Mendelian Randomization Study and Cross-Sectional Neuroimaging Study.The world journal of men's health · 2026Article
- The Habenula's role in major depressive disorder: recent insights from preclinical and human studies.Translational psychiatry · 2026Review
- Altered volumetric and functional connectivity of the habenula in chronic insomnia disorder.Frontiers in neuroscience · 2026Article
- Segmentation and Volume Estimation of the Habenula Using Deep Learning in Patients With Depression.Biological psychiatry global open science · 2024Article
- Visualizing the Habenula Using 3T High-Resolution MP2RAGE and QSM: A Preliminary Study.AJNR. American journal of neuroradiology · 2024Article
- Altered habenular connectivity in chronic low back pain: An fMRI and machine learning study.Human brain mapping · 2023Article
- Functional MRI markers for treatment-resistant depression: Insights and challenges.Progress in brain research · 2023Review
- Decreased resting-state functional connectivity of the habenula-cerebellar in a major depressive disorder.Frontiers in psychiatry · 2022Article
- Reduced habenular volumes and neuron numbers in male heroin addicts: a post-mortem study.European archives of psychiatry and clinical neuroscience · 2021Article
- Functional connectivity between the amygdala and subgenual cingulate gyrus predicts the antidepressant effects of ketamine in patients with treatment-resistant depression.Neuropsychopharmacology reports · 2021Article
- Left-right asymmetric and smaller right habenula volume in major depressive disorder on high-resolution 7-T magnetic resonance imaging.PloS one · 2021Article
- A resting-state study of volumetric and functional connectivity of the habenular nucleus in treatment-resistant depression patients.Brain and behavior · 2019Article
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5 authors.
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Abstract
objectiveTo investigate the volumetric and functional connectivity of the habenular nucleus in treatment-resistant depression (TRD) patients using the resting-state functional magnetic resonance imaging (rs-fMRI) approach.
methodsA total of 15 TRD patients, who visited the Mental Health Institute of the First Hospital Affiliated with Jilin University between August 2014 and March 2015, along with 15 normal subjects, were enrolled into this study for structural and functional imaging. Functional connectivity analysis was performed using bilateral habenular nuclei as the region of interest in contrast to whole-brain voxels.
resultsNo significant difference of absolute volume was found in bilateral habenular nuclei between TRD patients and healthy controls, or after controlling for individual total intracranial volume. However, functional connectivity analysis showed increased connectivity between the right habenular nucleus with the medial superior frontal gyrus, anterior cingulate cortex and medial orbitofrontal gyrus, and decreased connectivity with the corpus callosum in the TRD group. For the left habenular nucleus seed, the brain region with increased functional connectivity in the inferior temporal gyrus and decreased functional connectivity in the insular was found in the TRD patients.
conclusionAbnormal functional connectivity was present between the habenular nucleus and the default mode network in TRD patients. Dysfunction in habenular nucleus-related circuitry for processing negative emotion might form the pathological basis for TRD. Significant asymmetric functional connectivity was also found between bilateral habenular nuclei in TRD patients. Such asymmetry suggests potentially divergent strategy for intervention on bilateral habenular nucleus regions in the future management of depression.
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