Evidence map›Paper›PMID 30805909›Full record

ReviewMolecular biotechnology2019

Yeast Expression Systems: Overview and Recent Advances.

Roghayyeh Baghban, Safar Farajnia, Masoumeh Rajabibazl, Younes Ghasemi, AmirAli Mafi, Reyhaneh Hoseinpoor, Leila Rahbarnia, Maryam Aria

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

97 citing papers in PubMed.

  1. Metabolic engineering ofApplied and environmental microbiology · 2026
    Review
  2. Article
  3. Engineering of plant-derived P450scc forSynthetic and systems biotechnology · 2026
    Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. β-galactanase: an effective tool for the degradation of plant β-ᴅ-galactan.World journal of microbiology & biotechnology · 2025
    Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Functional Characterization ofInternational journal of molecular sciences · 2025
    Article
  18. Article
  19. Patterns of spontaneous and induced genomic alterations inApplied and environmental microbiology · 2025
    Article
  20. Genome-Wide Identification ofInternational journal of molecular sciences · 2025
    Article

37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Roghayyeh BaghbanMedical Biotechnology Department, Faculty of Advanced Medical Science, Tabriz University of Medical Sciences, Tabriz, Iran.
Safar FarajniaBiotechnology Research Center, Tabriz University of Medical Sciences, Daneshgah Ave, Tabriz, Iran. farajnias@tbzmed.ac.ir.
Masoumeh RajabibazlDepartment of Clinical Biochemistry, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Velenjak, Arabi Ave, Tehran, Iran. rajabi_m@sbmu.ac.ir.
Younes GhasemiDepartment of Pharmaceutical Biotechnology, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Shiraz University of Medical Science, Shiraz, Iran.
AmirAli MafiAnesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Reyhaneh HoseinpoorDepartment of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Leila RahbarniaInfectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Maryam AriaBiotechnology Research Center, Tabriz University of Medical Sciences, Daneshgah Ave, Tabriz, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Yeasts are outstanding hosts for the production of functional recombinant proteins with industrial or medical applications. Great attention has been emerged on yeast due to the inherent advantages and new developments in this host cell. For the production of each specific product, the most appropriate expression system should be identified and optimized both on the genetic and fermentation levels, considering the features of the host, vector and expression strategies. Currently, several new systems are commercially available; some of them are private and need licensing. The potential for secretory expression of heterologous proteins in yeast proposed this system as a candidate for the production of complex eukaryotic proteins. The common yeast expression hosts used for recombinant proteins' expression include Saccharomyces cerevisiae, Pichia pastoris, Hansenula polymorpha, Yarrowia lipolytica, Arxula adeninivorans, Kluyveromyces lactis, and Schizosaccharomyces pombe. This review is dedicated to discuss on significant characteristics of the most common methylotrophic and non-methylotrophic yeast expression systems with an emphasis on their advantages and new developments.

Indexed as

PhylogenyProtein EngineeringRecombinant ProteinsTransgenesYeastsRecombinant ProteinsExpression systemHansenula polymorphaPichia pastorisSaccharomyces cerevisiaeYarrowia lipolytica

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.