Evidence map›Paper›PMID 30805813›Full record

ArticleCancer causes & control : CCC2019

Cancer incidence in the Agricultural Health Study after 20 years of follow-up.

Catherine C Lerro, Stella Koutros, Gabriella Andreotti, Dale P Sandler, Charles F Lynch, Lydia M Louis, Aaron Blair, Christine G Parks, Srishti Shrestha, Jay H Lubin and 3 more

Open access · greenAbstract read
In one paragraph

Article in Cancer causes & control : CCC, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 4 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 4 syntheses or guidelines pooled it, 71 citations in OpenAlex.

  1. Time for Re-Evaluating the Human Carcinogenicity of Ethylenedithiocarbamate Fungicides? A Systematic Review.International journal of environmental research and public health · 2022
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  10. Agricultural exposures and DNA damage in PBMC of female farmers measured using the alkaline comet assay.International archives of occupational and environmental health · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Catherine C LerroOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6E116, 9609 Medical Center Drive, Rockville, MD, 20850, USA. catherine.lerro@nih.gov.ORCID http://orcid.org/0000-0002-8765-938X
Stella KoutrosOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6E116, 9609 Medical Center Drive, Rockville, MD, 20850, USA.
Gabriella AndreottiOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6E116, 9609 Medical Center Drive, Rockville, MD, 20850, USA.
Dale P SandlerNational Institute of Environmental Health Sciences, 111 T.W. Alexander Drive, Research Triangle Park, NC, 27709, USA.
Charles F LynchDepartment of Epidemiology, University of Iowa, 145 N. Riverside Drive, Iowa City, IA, 52242, USA.
Lydia M LouisOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6E116, 9609 Medical Center Drive, Rockville, MD, 20850, USA.
Aaron BlairOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6E116, 9609 Medical Center Drive, Rockville, MD, 20850, USA.
Christine G ParksNational Institute of Environmental Health Sciences, 111 T.W. Alexander Drive, Research Triangle Park, NC, 27709, USA.
Srishti ShresthaNational Institute of Environmental Health Sciences, 111 T.W. Alexander Drive, Research Triangle Park, NC, 27709, USA.
Jay H LubinBiostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Drive, Rockville, MD, 20850, USA.
Paul S AlbertBiostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Drive, Rockville, MD, 20850, USA.
Jonathan N HofmannOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6E116, 9609 Medical Center Drive, Rockville, MD, 20850, USA.
Laura E Beane FreemanOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6E116, 9609 Medical Center Drive, Rockville, MD, 20850, USA.
National Cancer Institute · USNational Institute of Environmental Health Sciences · USUniversity of Iowa · US

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Christopher K Laubenthal · 2000 to 2026
$70.0M
Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5M
Health Effects Of Exposures In AgricultureZIAES049030 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI SANDLER, DALE P · 2009 to 2025
$11.2M
STUDIES OF OCCUPATIONAL CANCER--PESTICIDESZ01CP010119 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI ALAVANJA, MICHAEL · 1996 to 2008
$5.0M
HEALTH EFFECTS OF EXPOSURES IN AGRICULTUREZ01ES049030 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI SANDLER, DALE P · 1997 to 2008
$889k
Intramural NIH HHS Z01 CP010119Intramural NIH HHS Z01 ES049030Intramural NIH HHS Z99 CA999999NCI NIH HHS Z01-CP010119NIEHS NIH HHS P30 ES005605NIEHS NIH HHS Z01-ES049030
6 · The paper itself

Abstract

purposeTo evaluate cancer incidence in the Agricultural Health Study (AHS), a cohort of private pesticide applicators, their spouses, and commercial applicators, based on 12,420 cancers, adding 5,989 cancers, and 9 years of follow-up since last evaluation.

methodsWe calculated age, year, sex, and race-adjusted standardized incidence ratios (SIR) and 95% confidence intervals (CI) for cancer sites in the AHS relative to the general population.

resultsOverall AHS cancer incidence was lower than the general population (SIR

conclusionsAlthough an overall deficit in cancer was observed, there were notable exceptions, including newly observed excesses for AML, thyroid, testicular, and peritoneal cancers. Furthermore, endotoxin exposure may, in part, account for observed lung cancer incidence deficits. Cancer incidence patterns in the AHS suggest farm exposures' relevance to cancer etiology.

Indexed as

PesticidesAgedCohort StudiesFemaleFollow-Up StudiesHumansIncidenceMaleMiddle AgedNeoplasmsOccupational ExposureSpousesPesticidesCancerEndotoxinFarmingIncidencePesticides

Identifiers

PMID30805813
PMCPMC6459699
OpenAlexW2917174372

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.