Evidence map›Paper›PMID 30805758›Full record

ArticleJournal of thrombosis and thrombolysis2019

Characterisation of acute ischemic stroke in patients with left ventricular thrombi after myocardial infarction.

Aloysius Sheng-Ting Leow, Ching-Hui Sia, Benjamin Yong-Qiang Tan, Rajinderdeep Kaur, Tiong-Cheng Yeo, Mark Yan-Yee Chan, Edgar Lik-Wui Tay, Raymond Chee-Seong Seet, Joshua Ping-Yun Loh, Leonard Leong-Litt Yeo

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In one paragraph

Article in Journal of thrombosis and thrombolysis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

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  15. Left ventricular thrombus recurrence after anticoagulation discontinuation.International journal of cardiology. Heart & vasculature · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Aloysius Sheng-Ting LeowYong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. leowaloysius@hotmail.com.ORCID http://orcid.org/0000-0003-3659-1650
Ching-Hui SiaDepartment of Cardiology, National University Heart Centre, Singapore, Singapore.
Benjamin Yong-Qiang TanDivision of Neurology, Department of Medicine, National University Health System, Singapore, Singapore.
Rajinderdeep KaurDepartment of Cardiology, National University Heart Centre, Singapore, Singapore.
Tiong-Cheng YeoDepartment of Cardiology, National University Heart Centre, Singapore, Singapore.
Mark Yan-Yee ChanDepartment of Cardiology, National University Heart Centre, Singapore, Singapore.
Edgar Lik-Wui TayDepartment of Cardiology, National University Heart Centre, Singapore, Singapore.
Raymond Chee-Seong SeetDivision of Neurology, Department of Medicine, National University Health System, Singapore, Singapore.
Joshua Ping-Yun LohDepartment of Cardiology, National University Heart Centre, Singapore, Singapore.
Leonard Leong-Litt YeoDivision of Neurology, Department of Medicine, National University Health System, Singapore, Singapore.
National University of Singapore · SGNational University Heart Centre Singapore · SGNational University Health System · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute ischemic stroke (AIS) is a feared complication in post-acute myocardial infarction (AMI) patients who develop left ventricular (LV) thrombus. There is limited data available on the incidence of stroke in this population, and characterisation of stroke subtypes has not been previously reported. Our study aims to evaluate the incidence of AIS in post-AMI patients with LV thrombus and to characterise the pattern of stroke subtypes. We screened 5829 patients with echocardiogram reports containing the "thrombus" keyword from August 2006 to September 2017. AIS that occurred after LV thrombosis was captured and relevant clinical data was collected. We identified 289 post-AMI patients with acute LV thrombus formation. Mean age was 59.3 ± 13.4 years. AIS occurred in 34 patients (11.8%), median duration of 20.5 days (IQR = 5.5-671.8) after LV thrombosis. Despite initial thrombus resolution, nine (5.2%) encountered AIS subsequently. Cardioembolic stroke subtype was identified in 76.5% of AIS, whilst 14.7% was small vessel disease and 8.8% was of large artery atherosclerosis subtype. Presence of thrombus protrusion (HR 3.04, 95% CI 1.25-7.41, p = 0.01), failure of initial thrombus resolution (HR 3.03, 95% CI 1.23-7.45, p = 0.02) and thrombus recurrence (HR 4.20, 95% CI 1.46-12.11, p < 0.01) were significant independent predictors for stroke. Incidence of AIS in this Asian population of post-AMI patients with LV thrombus was 11.8%. Duration of anticoagulation may need to be individualised for patients with higher risk for stroke occurrence after LV thrombosis.

Indexed as

AgedBrain IschemiaFemaleHumansIncidenceMaleMiddle AgedMyocardial InfarctionRisk FactorsStrokeThrombosisVentricular Dysfunction, LeftAcute ischemic strokeAcute myocardial infarctionAnticoagulationCardioembolismLeft ventricular thrombus

Identifiers

PMID30805758
OpenAlexW2917352617

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.