ArticleThe Journal of infectious diseases2019
Tracing the Impact of Public Health Interventions on HIV-1 Transmission in Portugal Using Molecular Epidemiology.
Article in The Journal of infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Phylogenetics and molecular evolution to understand and curb the HIV pandemic.Nature reviews. Microbiology · 2026Review
- Characterising HIV-1 transmission in Victoria, Australia: a molecular epidemiological study.The Lancet regional health. Western Pacific · 2024Article
- HIV-1 transmission dynamics among people who inject drugs on the US/Mexico border during the COVID-19 pandemic: a prosepective cohort study.Lancet regional health. Americas · 2024Article
- Molecular epidemiology of the HIV-1 epidemic in Fiji.Npj viruses · 2024Article
- Toward a global virus genomic surveillance network.Cell host & microbe · 2023Review
- Article
- Epidemiological inference from pathogen genomes: A review of phylodynamic models and applications.Virus evolution · 2022Review
- Molecular Epidemiology and Transmission Dynamics of the HIV-1 Epidemic in Ethiopia: Epidemic Decline Coincided With Behavioral Interventions Before ART Scale-Up.Frontiers in microbiology · 2022Article
- Epidemiology and Molecular Transmission Characteristics of HIV in the Capital City of Anhui Province in China.Pathogens (Basel, Switzerland) · 2021Article
- Independent epidemic patterns of HIV-1 CRF01_AE lineages driven by mobile population in Shenzhen, an immigrant city of China.Virus evolution · 2021Article
- Fundamental Identifiability Limits in Molecular Epidemiology.Molecular biology and evolution · 2021Article
- The Viral Founder Effect and Economic-Driven Human Mobility Shaped the Distinct Epidemic Pattern of HIV-1 CRF01_AE in Northeast China.Frontiers in medicine · 2021Article
- Subtype-specific differences in transmission cluster dynamics of HIV-1 B and CRF01_AE in New South Wales, Australia.Journal of the International AIDS Society · 2021Article
- Article
- Dynamics of HIV-1 Molecular Networks Reveal Effective Control of Large Transmission Clusters in an Area Affected by an Epidemic of Multiple HIV Subtypes.Frontiers in microbiology · 2020Article
- Phylogenetics applied to the human immunodeficiency virus type 1 (HIV-1): from the cross-species transmissions to the contact network inferences.Memorias do Instituto Oswaldo Cruz · 2020Article
- Article
- Advances in Visualization Tools for Phylogenomic and Phylodynamic Studies of Viral Diseases.Frontiers in public health · 2019Review
- Informed Consent in Molecular HIV Epidemiology: A Rapid Review of the Literature to Identify Concerns and Recommendations.Public health reports (Washington, D.C. : 1974)Review
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Authors and funding
11 authors.
Funding
Abstract
backgroundEstimation of temporal changes in human immunodeficiency virus (HIV) transmission patterns can help to elucidate the impact of preventive strategies and public health policies.
methodsPortuguese HIV-1 subtype B and G pol genetic sequences were appended to global reference data sets to identify country-specific transmission clades. Bayesian birth-death models were used to estimate subtype-specific effective reproductive numbers (Re). Discrete trait analysis (DTA) was used to quantify mixing among transmission groups.
resultsWe identified 5 subtype B Portuguese clades (26-79 sequences) and a large monophyletic subtype G Portuguese clade (236 sequences). We estimated that major shifts in HIV-1 transmission occurred around 1999 (95% Bayesian credible interval [BCI], 1998-2000) and 2000 (95% BCI, 1998-2001) for subtypes B and G, respectively. For subtype B, Re dropped from 1.91 (95% BCI, 1.73-2.09) to 0.62 (95% BCI,.52-.72). For subtype G, Re decreased from 1.49 (95% BCI, 1.39-1.59) to 0.72 (95% BCI, .63-.8). The DTA suggests that people who inject drugs (PWID) and heterosexuals were the source of most (>80%) virus lineage transitions for subtypes G and B, respectively.
conclusionsThe estimated declines in Re coincide with the introduction of highly active antiretroviral therapy and the scale-up of harm reduction for PWID. Inferred transmission events across transmission groups emphasize the importance of prevention efforts for bridging populations.
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