Evidence map›Paper›PMID 30805597›Full record

ArticleArchives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists2019

A Cross-Sectional Investigation of Cognition and Ultrasound-Based Vascular Strain Indices.

N H Meshram, D Jackson, T Varghese, C C Mitchell, S M Wilbrand, R J Dempsey, B P Hermann

Abstract read
In one paragraph

Article in Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Mask R-CNN-based carotid plaque localization in ultrasound images.Journal of medical imaging (Bellingham, Wash.) · 2026
    Article
  2. Lagrangian deformation tracking for strain imaging.Progress in biomedical engineering (Bristol, England) · 2026
    Review
  3. Article
  4. Article
  5. Study of the Relationship Between Ultrasound Strain Indices and Cognitive Decline for Vulnerable Carotid Plaque.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2020
    Article
  6. Article
  7. Biomedical physics & engineering express · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

N H MeshramDepartment of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
D JacksonDepartment of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
T VargheseDepartment of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
C C MitchellDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
S M WilbrandDepartment of Neurological Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
R J DempseyDepartment of Neurological Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
B P HermannDepartment of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

Funding

Real-time Ultrasonic Monitoring of Tumor AblationR01CA112192 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI VARGHESE, TOMY · 2007 to 2017
$2.6M
Structural Stability of Carotid Plaque and SymptomatologyR01NS064034 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI DEMPSEY, ROBERT J · 2010 to 2014
$1.5M
NCI NIH HHS R01 CA112192NINDS NIH HHS R01 NS064034
6 · The paper itself

Abstract

objectiveWe examine the relationship between variability in the plaque strain distribution estimated using ultrasound with multiple cognitive domains including executive, language, visuospatial reasoning, and memory function.

methodAsymptomatic (n = 42) and symptomatic (n = 34) patients with significant (>60%) carotid artery stenosis were studied for plaque instability using ultrasound strain imaging and multiple cognitive domains including executive, language, visuospatial reasoning, and memory function. Correlation and ROC analyses were performed between ultrasound strain indices and cognitive function. Strain indices and cognition scores were also compared between symptomatic and asymptomatic patients to determine whether there are significant group differences.

resultsAssociation of high-strain distributions with dysexecutive function was observed in both asymptomatic and symptomatic patients. For memory, visuospatial, and language functions, the correlations between strain and cognition were weaker for the asymptomatic compared to symptomatic group.

conclusionsBoth asymptomatic and symptomatic patients demonstrate a relationship between vessel strain indices and executive function indicating that silent strokes and micro-emboli could initially contribute to a decline in executive function, whereas strokes and transient ischemic attacks may cause the further decline in other cognitive functions.

Indexed as

CognitionAgedCarotid StenosisCross-Sectional StudiesExecutive FunctionFemaleHumansLanguageMaleMemoryMiddle AgedNeuropsychological TestsPlaque, AtheroscleroticUltrasonographyCarotid stenosisCerebrovascular diseaseCognitive impairmentEarly diagnosisExecutive functioningNeuropsychological tests

Identifiers

PMID30805597
PMCPMC7014973

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.