ArticleJournal of the Endocrine Society2019
Age-Dependent Progression of Renal Dysfunction After Adrenalectomy for Aldosterone-Producing Adenomas in Japan.
Article in Journal of the Endocrine Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 7 citations in OpenAlex.
- Chronological outcomes of renal function after adrenalectomy in patients with primary aldosteronism across age groups.Frontiers in endocrinology · 2024Article
- Emerging association between KCNJ5 mutations and vascular failure in primary aldosteronism.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
- Persistent severe hyperkalemia following surgical treatment of aldosterone-producing adenoma.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2020Article
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Authors and funding
16 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
contextIn patients with aldosterone-producing adenomas (APAs), adrenalectomy causes a rapid decrease in blood pressure and increase in blood potassium levels; however, the effects of these intensive metabolic changes on kidney function with age have not yet been examined in Japan.
objectiveTo investigate factors related to the progression of kidney dysfunction after adrenalectomy in different age groups.
participantsFifty Japanese patients with APAs and 27,572 health checkup patients as controls were examined.
main outcome measuresWe investigated changes in estimated glomerular filtration rate (eGFR) after adrenalectomy and characterized patients who progressed to chronic kidney disease (CKD).
resultsThe postoperative cutoff age of CKD is 50 years and age is a unique factor for the progression of CKD after adrenalectomy. Among preoperative patients, CKD was 6% for those <50 years old and 40% for those ≥50 years old, indicating a higher prevalence of CKD with APAs than in control subjects. Median eGFR <50 mL/min/1.73 m
conclusionAge is the most important predictor of the progression of kidney dysfunction after adrenalectomy in Japanese patients with APAs, particularly those with a history of cardiovascular events and positivity for KCNJ5 mutations.
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