Evidence map›Paper›PMID 30805422›Full record

ArticleBone reports2019

Insulin Receptor deletion in S100a4-lineage cells accelerates age-related bone loss.

Valentina Studentsova, Emma Knapp, Alayna E Loiselle

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. CD4Combinatorial chemistry & high throughput screening · 2026
    Article
  3. Review
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Valentina StudentsovaCenter for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY 14642, United States of America.
Emma KnappCenter for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY 14642, United States of America.
Alayna E LoiselleCenter for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY 14642, United States of America.
University of Rochester Medical Center · US

Funding

Rochester Resource-Based Center for Bone, Muscle and Orthopaedic Research (ROCSTARR) (Overall Application)P30AR069655 · NIAMS · UNIVERSITY OF ROCHESTER · PI Edward M. Schwarz · 2016 to 2026
$7.8M
s100a4 Signaling in Fibrotic Diabetic Tendon HealingR01AR073169 · NIAMS · UNIVERSITY OF ROCHESTER · PI LOISELLE, ALAYNA · 2018 to 2022
$1.7M
Defining the relationship between attenuated insulin receptor signaling and fibrosis in diabetic tendinopathyK01AR068386 · NIAMS · UNIVERSITY OF ROCHESTER · PI LOISELLE, ALAYNA · 2016 to 2019
$484k
NIAMS NIH HHS K01 AR068386NIAMS NIH HHS P30 AR069655NIAMS NIH HHS R01 AR073169
6 · The paper itself

Abstract

Type I and Type II Diabetes dramatically impair skeletal health. Altered Insulin Receptor (IR) signaling is a common feature of both diseases, and insulin has potent bone anabolic functions. Several previous studies have demonstrated that loss of IR in bone cells results in disrupted bone homeostasis during early post-natal growth. Here we have deleted IR in S100a4-lineage cells (IRcKO

Indexed as

AgingBoneBone homeostasisInsulin receptorS100a4

Identifiers

PMID30805422
PMCPMC6374520
OpenAlexW2950279967

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.