Evidence map›Paper›PMID 30805086›Full record

ArticleOxidative medicine and cellular longevity2019

Isoliquiritigenin Induces Mitochondrial Dysfunction and Apoptosis by Inhibiting mitoNEET in a Reactive Oxygen Species-Dependent Manner in A375 Human Melanoma Cells.

Xiao-Yu Chen, Huan-Huan Ren, Dan Wang, Ying Chen, Chuan-Jun Qu, Zhao-Hai Pan, Xiao-Na Liu, Wen-Jin Hao, Wen-Juan Xu, Ke-Jun Wang and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 38 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. [Isoliquiritigenin Modulates the Effect of LINC01503 
on Lung Squamous Carcinoma Cells].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2024
    Article
  10. Review
  11. Anticancer Potential of Natural Chalcones: In Vitro and In Vivo Evidence.International journal of molecular sciences · 2023
    Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Xiao-Yu ChenSchool of Integrated Traditional Chinese and Western Medicine, Binzhou Medical University, Yantai, 264003 Shandong, China.ORCID 0000-0003-3561-9746
Huan-Huan RenKey Laboratory of Xinjiang Endemic Phytomedicine Resources of Ministry of Education, School of Pharmacy, Shihezi University, Shihezi, 832002 Xinjiang, China.ORCID 0000-0001-6539-1522
Dan WangSchool of Integrated Traditional Chinese and Western Medicine, Binzhou Medical University, Yantai, 264003 Shandong, China.
Ying ChenSchool of Integrated Traditional Chinese and Western Medicine, Binzhou Medical University, Yantai, 264003 Shandong, China.
Chuan-Jun QuSchool of Integrated Traditional Chinese and Western Medicine, Binzhou Medical University, Yantai, 264003 Shandong, China.
Zhao-Hai PanSchool of Integrated Traditional Chinese and Western Medicine, Binzhou Medical University, Yantai, 264003 Shandong, China.
Xiao-Na LiuSchool of Integrated Traditional Chinese and Western Medicine, Binzhou Medical University, Yantai, 264003 Shandong, China.ORCID 0000-0001-8934-056X
Wen-Jin HaoSchool of Integrated Traditional Chinese and Western Medicine, Binzhou Medical University, Yantai, 264003 Shandong, China.ORCID 0000-0002-7494-0543
Wen-Juan XuSchool of Integrated Traditional Chinese and Western Medicine, Binzhou Medical University, Yantai, 264003 Shandong, China.
Ke-Jun WangSchool of Integrated Traditional Chinese and Western Medicine, Binzhou Medical University, Yantai, 264003 Shandong, China.ORCID 0000-0002-6622-1039
De-Fang LiSchool of Integrated Traditional Chinese and Western Medicine, Binzhou Medical University, Yantai, 264003 Shandong, China.ORCID 0000-0003-4151-9151
Qiu-Sheng ZhengSchool of Integrated Traditional Chinese and Western Medicine, Binzhou Medical University, Yantai, 264003 Shandong, China.ORCID 0000-0001-6413-9878
Binzhou Medical University · CNShihezi University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mitochondrial protein mitoNEET is a type of iron-sulfur protein localized to the outer membrane of mitochondria and is involved in a variety of human pathologies including cystic fibrosis, diabetes, muscle atrophy, and neurodegeneration. In the current study, we found that isoliquiritigenin (ISL), one of the components of the root of

Indexed as

ApoptosisCell Line, TumorCell ProliferationChalconesHumansMelanomaMitochondriaMitochondrial ProteinsReactive Oxygen SpeciesChalconesCISD1 protein, humanisoliquiritigeninMitochondrial ProteinsReactive Oxygen Species

Identifiers

PMID30805086
PMCPMC6360568
OpenAlexW2910753751

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.