Evidence map›Paper›PMID 30804933›Full record

ReviewFrontiers in immunology2019

T and B Cell Immune Responses to Influenza Viruses in Pigs.

Barbara Holzer, Veronica Martini, Matthew Edmans, Elma Tchilian

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Virulence · 2026
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  19. Comparative Analysis ofVeterinary sciences · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Barbara HolzerDepartment of Mucosal Immunology, The Pirbright Institute (BBSRC), Pirbright, United Kingdom.
Veronica MartiniDepartment of Mucosal Immunology, The Pirbright Institute (BBSRC), Pirbright, United Kingdom.
Matthew EdmansDepartment of Mucosal Immunology, The Pirbright Institute (BBSRC), Pirbright, United Kingdom.
Elma TchilianDepartment of Mucosal Immunology, The Pirbright Institute (BBSRC), Pirbright, United Kingdom.

Funding

Biotechnology and Biological Sciences Research Council BB/L001330/1Biotechnology and Biological Sciences Research Council BBS/E/I/00007031
6 · The paper itself

Abstract

Influenza viruses are an ongoing threat to humans and are endemic in pigs, causing considerable economic losses to farmers. Pigs are also a source of new viruses potentially capable of initiating human pandemics. Many tools including monoclonal antibodies, recombinant cytokines and chemokines, gene probes, tetramers, and inbred pigs allow refined analysis of immune responses against influenza. Recent advances in understanding of the pig innate system indicate that it shares many features with that of humans, although there is a larger gamma delta component. The fine specificity and mechanisms of cross-protective T cell immunity have yet to be fully defined, although it is clear that the local immune response is important. The repertoire of pig antibody response to influenza has not been thoroughly explored. Here we review current understanding of adaptive immune responses against influenza in pigs and the use of the pig as a model to study human disease.

Indexed as

Adaptive ImmunityAnimalsB-LymphocytesDisease Models, AnimalHumansInfluenza, HumanOrthomyxoviridaeOrthomyxoviridae InfectionsPandemicsSwineSwine DiseasesT-LymphocytesLAIV (live attenuated influenza vaccine)local T cell immunitymucosal immunityneuraminidasepeptide SLA-Tetramerswine influenza virus (SIV)T cell responsesVAERD

Identifiers

PMID30804933
PMCPMC6371849

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.