Evidence map›Paper›PMID 30804928›Full record

ArticleFrontiers in immunology2019

The PD-1/PD-L1 Pathway Affects the Expansion and Function of Cytotoxic CD8

Paul David, Dominik A Megger, Tamara Kaiser, Tanja Werner, Jia Liu, Lieping Chen, Barbara Sitek, Ulf Dittmer, Gennadiy Zelinskyy

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 41 citations in OpenAlex.

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  14. SerumPeerJ · 2021
    Article
  15. Article
  16. Review
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  18. Article
  19. Review
  20. Treatment Guidance for Patients With Lung Cancer During the Coronavirus 2019 Pandemic.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Paul DavidInstitute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Dominik A MeggerMedizinisches Proteom-Center, Ruhr-Universität Bochum, Bochum, Germany.
Tamara KaiserInstitute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Tanja WernerInstitute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Jia LiuInstitute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Lieping ChenDepartment of Immunobiology, Yale School of Medicine, Yale University, New Haven, CT, United States.
Barbara SitekMedizinisches Proteom-Center, Ruhr-Universität Bochum, Bochum, Germany.
Ulf DittmerInstitute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Gennadiy ZelinskyyInstitute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
University of Duisburg-Essen · DERuhr University Bochum · DEUnion Hospital · CNYale University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytotoxic CD8

Indexed as

Signal TransductionAnimalsApoptosisB7-H1 AntigenCaspasesCytotoxicity, ImmunologicDisease Models, AnimalMiceMice, TransgenicProgrammed Cell Death 1 ReceptorProteomeProteomicsRetroviridaeRetroviridae InfectionsT-Lymphocytes, CytotoxicB7-H1 AntigenCaspasesCD274 protein, humanProgrammed Cell Death 1 ReceptorProteomeapoptosiscaspase 3CD8 T cellsimmunoregulationPD-1PD-L1retrovirus

Identifiers

PMID30804928
PMCPMC6370637
OpenAlexW2914322301

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.