Evidence map›Paper›PMID 30804821›Full record

ArticleFrontiers in psychiatry2019

A Data Science-Based Analysis Points at Distinct Patterns of Lipid Mediator Plasma Concentrations in Patients With Dementia.

Robert Gurke, Semra Etyemez, David Prvulovic, Dominique Thomas, Stefanie C Fleck, Andreas Reif, Gerd Geisslinger, Jörn Lötsch

Open access · goldAbstract read
In one paragraph

Article in Frontiers in psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Robert GurkeInstitute of Clinical Pharmacology, University Hospital of Frankfurt, Goethe-University, Frankfurt, Germany.
Semra EtyemezDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital of Frankfurt, Goethe-University, Frankfurt, Germany.
David PrvulovicDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital of Frankfurt, Goethe-University, Frankfurt, Germany.
Dominique ThomasInstitute of Clinical Pharmacology, University Hospital of Frankfurt, Goethe-University, Frankfurt, Germany.
Stefanie C FleckFraunhofer Institute for Molecular Biology and Applied Ecology IME, Branch for Translational Medicine and Pharmacology TMP, Frankfurt, Germany.
Andreas ReifDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital of Frankfurt, Goethe-University, Frankfurt, Germany.
Gerd GeisslingerInstitute of Clinical Pharmacology, University Hospital of Frankfurt, Goethe-University, Frankfurt, Germany.
Jörn LötschInstitute of Clinical Pharmacology, University Hospital of Frankfurt, Goethe-University, Frankfurt, Germany.
Goethe University Frankfurt · DEUniversity Hospital Frankfurt · DEFraunhofer Institute for Molecular Biology and Applied Ecology · DEFraunhofer Institute for Translational Medicine and Pharmacology · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Based on accumulating evidence of a role of lipid signaling in many physiological and pathophysiological processes including psychiatric diseases, the present data driven analysis was designed to gather information needed to develop a prospective biomarker, using a targeted lipidomics approach covering different lipid mediators. Using unsupervised methods of data structure detection, implemented as hierarchal clustering, emergent self-organizing maps of neuronal networks, and principal component analysis, a cluster structure was found in the input data space comprising plasma concentrations of

Indexed as

biomarkerdata sciencedementialipidsmachine learning

Identifiers

PMID30804821
PMCPMC6378270
OpenAlexW2914608277

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.