Evidence map›Paper›PMID 30804809›Full record

ArticleFrontiers in physiology2019

C-Reactive Protein Is Elevated Only in High Creatine Kinase Responders to Muscle Damaging Exercise.

Ashwin W Isaacs, Filippo Macaluso, Carine Smith, Kathryn H Myburgh

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07113405 (The Influence of Tea Extract on Maximal Voluntary Knee Contraction After 30 Minutes of Downhill Jogging), which is not on this map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07113405 narecruitingnot on this mapstarted 2025, after this paper: background citation

The Influence of Tea Extract on Maximal Voluntary Knee Contraction After 30 Minutes of Downhill Jogging: a Randomized, Double-blind, Placebo-controlled Study

TypeinterventionalSponsorUniversity of FribourgRan2025 to 2026Enrolled60ConditionsMuscle RecoveryArmsProtein and tea extract, Protein, Placebo
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Efficacy ofNutrients · 2024
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  19. Mitochondrial Dysfunctions and Potential Molecular Markers in Sport Horses.International journal of molecular sciences · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Ashwin W IsaacsDepartment of Physiological Sciences, Stellenbosch University, Stellenbosch, South Africa.
Filippo MacalusoDepartment of Physiological Sciences, Stellenbosch University, Stellenbosch, South Africa.
Carine SmithDepartment of Physiological Sciences, Stellenbosch University, Stellenbosch, South Africa.
Kathryn H MyburghDepartment of Physiological Sciences, Stellenbosch University, Stellenbosch, South Africa.
Stellenbosch University · ZAUniversity of Palermo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of this study was to investigate if exertional rhabdomyolysis induced by an acute bout of plyometric exercise in untrained individuals was associated with histological characteristics of skeletal muscle, creatine kinase (CK) polymorphism or secondary damage. Twenty-six healthy male untrained individuals completed a bout of plyometric exercise (10 sets of 10 maximal squat jumps, with each standardized to achieve at least 95% of individual maximal jump height). Blood samples were taken, and perceived pain was scored immediately before the exercise intervention and 6 h, 1, 2, and 3 days post-intervention. Muscle biopsies were collected 9 or 4 days before (baseline) and 3 days after plyometric jumps. Subjects were divided into two groups, high (

Indexed as

creatine kinaseeccentric exercise and muscle damagemyeloperoxidasemyoglobinsingle nucleotide polymorphism

Identifiers

PMID30804809
PMCPMC6378920
OpenAlexW2913242576

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.