ArticleNature genetics2019
Biological and clinical insights from genetics of insomnia symptoms.
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In one paragraph
Article in Nature genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 246 papers, 14 of them syntheses that pooled it.
0numbers the graph read from it
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246citing papers in PubMed, 14 pooled it
39.8field-weighted citation impact, top 1% of its field
What it found
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Who cites it
246 citing papers in PubMed, 14 syntheses or guidelines pooled it, 403 citations in OpenAlex.
- Identification of therapeutic targets for insomnia through genetic and plasma proteomic approaches.Medicine · 2025Pooled it
- Strengthening the reporting of observational studies in epidemiology using Mendelian randomization (STROBE-MR): a Korean translation of explanation and elaboration.Ewha medical journal · 2025Guideline
- Associations between insomnia and cardiovascular diseases: a meta-review and meta-analysis of observational and Mendelian randomization studies.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Pooled it
- Genetic estimation of causalities between educational attainment with common digestive tract diseases and the mediating pathways.BMC gastroenterology · 2024Pooled it
- Causal relationships between neuropsychiatric disorders and nonalcoholic fatty liver disease: A bidirectional Mendelian randomization study.BMC gastroenterology · 2024Pooled it
- Genome-wide meta-analyses of restless legs syndrome yield insights into genetic architecture, disease biology and risk prediction.Nature genetics · 2024Pooled it
- Genome-wide association studies and cross-population meta-analyses investigating short and long sleep duration.Nature communications · 2023Pooled it
- Multi-ancestry genome-wide analysis identifies shared genetic effects and common genetic variants for self-reported sleep duration.Human molecular genetics · 2023Pooled it
- Genome-wide association study of obstructive sleep apnoea in the Million Veteran Program uncovers genetic heterogeneity by sex.EBioMedicine · 2023Pooled it
- Morning chronotype and digestive tract cancers: Mendelian randomization study.International journal of cancer · 2023Pooled it
- Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways.Nature genetics · 2022Pooled it
- The causal relationship between sleep traits and the risk of schizophrenia: a two-sample bidirectional Mendelian randomization study.BMC psychiatry · 2022Pooled it
- Pooled it
- Using Mendelian randomization analysis to better understand the relationship between mental health and substance use: a systematic review.Psychological medicine · 2021Pooled it
- Emotional Processing Following Digital Cognitive Behavioral Therapy for Insomnia in People With Depressive Symptoms: A Randomized Clinical Trial.JAMA network open · 2025Trial
- Molecular correlates of sleep deprivation in the mouse brain identified by meta-analysis of microarray data.Neurobiology of sleep and circadian rhythms · 2026Article
- Article
- Mitochondrial Function-Related Genes in Sleep Disorders: A Multi-Omics Mendelian Randomization Study.Journal of molecular neuroscience : MN · 2026Article
- Dissecting the shared genetic architecture and biological mechanisms linking sleep traits and suicide attempts: from variants to genes.Molecular psychiatry · 2026Article
- Genetic architecture of a Circadian Imbalance Index: genome-wide association, phenome-wide association, and Mendelian randomisation analyses.EBioMedicine · 2026Article
186 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
44 authors at 15 institutions in 5 countries.
Jacqueline M Lane *Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Samuel E Jones *Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK.ORCID http://orcid.org/0000-0003-0153-922X
Hassan S DashtiCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1650-679X
Andrew R WoodGenetics of Complex Traits, University of Exeter Medical School, Exeter, UK.
Krishna G AragamCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Vincent T van HeesNetherlands eScience Center, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0003-0182-9008
Linn B StrandK.G. Jebsen Centre for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
Bendik S WinsvoldK.G. Jebsen Centre for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.ORCID http://orcid.org/0000-0003-4171-8919
Heming WangBroad Institute, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-1486-7495
Jack BowdenMRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.
Yanwei SongCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Krunal PatelCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Simon G AndersonDivision of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.ORCID http://orcid.org/0000-0002-8896-073X
Robin N BeaumontGenetics of Complex Traits, University of Exeter Medical School, Exeter, UK.
David A BechtoldDivision of Endocrinology, Diabetes & Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.ORCID http://orcid.org/0000-0001-8676-8704
Brian E CadeBroad Institute, Cambridge, MA, USA.
Mary HaasCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Sekar KathiresanCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6724-032X
Max A LittleDepartment of Mathematics, Aston University, Birmingham, UK.
Annemarie I LuikSleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Andrew S LoudonDivision of Endocrinology, Diabetes & Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Shaun PurcellDepartment of Psychiatry, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.
Rebecca C RichmondSchool of Social and Community Medicine, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0003-0574-5071
Frank A J L ScheerBroad Institute, Cambridge, MA, USA.
Barbara SchormairInstitute of Neurogenomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Jessica TyrrellGenetics of Complex Traits, University of Exeter Medical School, Exeter, UK.
John W WinkelmanDepartments of Psychiatry and Neurology, Massachusetts General Hospital, Boston, MA, USA.
Juliane WinkelmannInstitute of Neurogenomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
HUNT All In Sleep
Kristian HveemK.G. Jebsen Centre for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
Chen ZhaoInstitute of Neurogenomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Jonas B NielsenFORMI and Department of Neurology, Oslo University Hospital, Oslo, Norway.ORCID http://orcid.org/0000-0002-6654-2852
Cristen J WillerDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-5645-4966
Susan RedlineDepartments of Medicine, Brigham and Women's Hospital and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Kai SpiegelhalderClinic for Psychiatry and Psychotherapy, Medical Centre-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Simon D KyleSleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
David W RayDivision of Endocrinology, Diabetes & Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.ORCID http://orcid.org/0000-0002-4739-6773
John-Anker ZwartK.G. Jebsen Centre for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
Ben BrumptonK.G. Jebsen Centre for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
Timothy M FraylingGenetics of Complex Traits, University of Exeter Medical School, Exeter, UK.
Deborah A Lawlor *MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0002-6793-2262
Martin K Rutter *Division of Endocrinology, Diabetes & Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Michael N Weedon *Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK.
Richa Saxena *Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. rsaxena@partners.org.ORCID http://orcid.org/0000-0003-2233-1065
Broad Institute · USUniversity of Exeter · GBBrigham and Women's Hospital · USNorwegian University of Science and Technology · NOOslo University Hospital · NOHelmholtz Zentrum München · DEUniversity of Manchester · GBAston University · GBErasmus MC · NLJohn Radcliffe Hospital · GBMassachusetts General Hospital · USNetherlands eScience Center · NLNortheastern University · USUniversity Medical Center Freiburg · DEUniversity of Bristol · GB
Funding
Phenotypic and Molecular Signatures for Sleep Apnea and Related MorbiditiesR35HL135818 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI REDLINE, SUSAN S. · 2017 to 2023
$7.2MBIOMETRIC-GENETIC ANALYSIS OF CARDIOVASCULAR DISEASET32HL007567 · NHLBI · LOUISIANA STATE UNIV HSC NEW ORLEANS · PI ZHU, XIAOFENG · 1985 to 2021
$6.0MLeveraging Family Data to Identify Genetic Variants for Sleep ApneaR01HL113338 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LIN, XIHONG, REDLINE, SUSAN S. · 2012 to 2016
$4.4MGenetics of chronotype and impact on metabolic diseaseR01DK107859 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Richa Saxena · 2016 to 2026
$4.0MMelatonin and Receptor Gene Variant: Linking Circadian System and Type 2 DiabetesR01DK102696 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI SAXENA, RICHA, SCHEER, FRANK A · 2015 to 2019
$3.8MStatistical methods for analyzing high-throughput genotype dataR01HG003054 · NHGRI · LOYOLA UNIVERSITY CHICAGO · PI ZHU, XIAOFENG · 2005 to 2017
$3.6MImpact of Malatonin, Food Timing and Receptor Variant on Type 2 Diabetes RiskR01DK105072 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI SAXENA, RICHA, SCHEER, FRANK A · 2016 to 2020
$3.2MGenetic and molecular basis of circadian rhythm disordersK01HL136884 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI LANE, JACQUELINE MARIE · 2018 to 2022
$848kWhole Genomic Characterization of Sleep Apnea Traits and Comorbid DisordersK01HL135405 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CADE, BRIAN EDMAND · 2017 to 2020
$695kDiscovery of genes for sleep traitsR21HL121728 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI SAXENA, RICHA · 2014 to 2015
$259kImpact of genetic variants on sleep timing and type 2 diabetes riskF32DK102323 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI LANE, JACQUELINE MARIE · 2015 to 2016
$116kMedical Research Council MC_PC_17228Medical Research Council MC_QA137853Medical Research Council MC_UU_00011/5Medical Research Council MC_UU_00011/6Medical Research Council MR/M005070/1Medical Research Council MR/P012167/1Medical Research Council MR/P023576/2NHGRI NIH HHS R01 HG003054NHLBI NIH HHS K01 HL135405NHLBI NIH HHS K01 HL136884NHLBI NIH HHS R01 HL113338NHLBI NIH HHS R21 HL121728NHLBI NIH HHS R35 HL135818NHLBI NIH HHS T32 HL007567NIDDK NIH HHS F32 DK102323NIDDK NIH HHS R01 DK102696NIDDK NIH HHS R01 DK105072NIDDK NIH HHS R01 DK107859Wellcome Trust 107851/Z/15/Z
Abstract
Insomnia is a common disorder linked with adverse long-term medical and psychiatric outcomes. The underlying pathophysiological processes and causal relationships of insomnia with disease are poorly understood. Here we identified 57 loci for self-reported insomnia symptoms in the UK Biobank (n = 453,379) and confirmed their effects on self-reported insomnia symptoms in the HUNT Study (n = 14,923 cases and 47,610 controls), physician-diagnosed insomnia in the Partners Biobank (n = 2,217 cases and 14,240 controls), and accelerometer-derived measures of sleep efficiency and sleep duration in the UK Biobank (n = 83,726). Our results suggest enrichment of genes involved in ubiquitin-mediated proteolysis and of genes expressed in multiple brain regions, skeletal muscle, and adrenal glands. Evidence of shared genetic factors was found between frequent insomnia symptoms and restless legs syndrome, aging, and cardiometabolic, behavioral, psychiatric, and reproductive traits. Evidence was found for a possible causal link between insomnia symptoms and coronary artery disease, depressive symptoms, and subjective well-being.
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AdultAgedCase-Control StudiesFemaleGene ExpressionGenetic Predisposition to DiseaseHumansMaleMiddle AgedProteolysisSelf ReportSleepSleep Initiation and Maintenance DisordersUbiquitinUbiquitin
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