ArticleNature genetics2019
Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations.
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In one paragraph
Article in Nature genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 240 papers, 8 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
240citing papers in PubMed, 8 pooled it
41.9field-weighted citation impact, top 1% of its field
What it found
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The trial behind it
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Who cites it
240 citing papers in PubMed, 8 syntheses or guidelines pooled it, 413 citations in OpenAlex.
- Potential drug targets for chronic obstructive pulmonary disease in the plasma proteome identified through Mendelian randomization.BMC pulmonary medicine · 2025Pooled it
- Genome-wide association study of preserved ratio impaired spirometry (PRISm).The European respiratory journal · 2024Pooled it
- X chromosome associations with chronic obstructive pulmonary disease and related phenotypes: an X chromosome-wide association study.Respiratory research · 2023Pooled it
- Pooled it
- Single-cell transcriptomics highlights immunological dysregulations of monocytes in the pathobiology of COPD.Respiratory research · 2022Pooled it
- Detailed stratified GWAS analysis for severe COVID-19 in four European populations.Human molecular genetics · 2022Pooled it
- Pooled it
- Soluble receptor for advanced glycation end products (sRAGE) as a biomarker of COPD.Respiratory research · 2021Pooled it
- Cell differentiation-related signaling pathways: biological functions, diseases and therapeutic targets.Signal transduction and targeted therapy · 2026Review
- Genetic variants in pulmonary hypertension associated with chronic obstructive pulmonary disease.Current opinion in pulmonary medicine · 2026Review
- Proteome-wide Mendelian randomisation of lung function to identify potential therapeutic targets for respiratory disease.ERJ open research · 2026Article
- Metabolomic profiling reveals distinct and shared biology in COPD and IPF.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Expanding CIRdb, a comprehensive catalog of whole-exome sequencing data of Canary Islanders.iScience · 2026Article
- Genome-wide association study of image-based emphysema scoring in the Swedish CArdioPulmonary bioImage Study (SCAPIS) suggests two new risk loci in smokers.Respiratory research · 2026Article
- Integrative Multivariate Genomics Identifies Shared Epithelial-Immune and Cytokine-Regulatory Mechanisms Across Major Chronic Lung Diseases.International journal of molecular sciences · 2026Article
- Disentangling Shared and Differential Genetic Architectures Between COVID-19 and Other Respiratory Disorders-A Genome-Wide Multi-Omics Framework.International journal of molecular sciences · 2026Article
- Defective alveolar regeneration in emphysema: identifying dysfunctional cellular crosstalk and novel therapeutic opportunities for tissue repair.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Article
- Investigating human lung resilience, its evolutionary history and its relation to COPD.American journal of physiology. Lung cellular and molecular physiology · 2026Review
- Observational
180 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
56 authors at 20 institutions in 18 countries.
Phuwanat Sakornsakolpat *Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4308-0974
Dmitry Prokopenko *Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1844-5652
Maxime LamontagneInstitut Universitaire de Cardiologie et de Pneumologie de Québec, Québec, Quebec, Canada.
Nicola F ReeveGenetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, UK.
Anna L GuyattGenetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, UK.ORCID http://orcid.org/0000-0003-1860-6337
Victoria E JacksonGenetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, UK.
Nick ShrineGenetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, UK.ORCID http://orcid.org/0000-0003-3641-4371
Dandi QiaoChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Traci M BartzCardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.
Deog Kyeom KimSeoul National University College of Medicine, SMG-SNU Boramae Medical Center, Seoul, South Korea.
Mi Kyeong LeeEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Raleigh, NC, USA.
Jeanne C LatourelleDepartment of Neurology, Boston University School of Medicine, Boston, MA, USA.
Xingnan LiDepartment of Medicine, University of Arizona, Tucson, AZ, USA.
Jarrett D MorrowChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Ma'en ObeidatUniversity of British Columbia Center for Heart Lung Innovation, St. Paul's Hospital, Vancouver, British Columbia, Canada.ORCID http://orcid.org/0000-0002-5443-2752
Annah B WyssEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Raleigh, NC, USA.
Per BakkeDepartment of Clinical Science, University of Bergen, Bergen, Norway.
R Graham BarrDepartment of Medicine, College of Physicians and Surgeons and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.
Terri H BeatyDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-7644-1705
Steven A BelinskyLovelace Respiratory Research Institute, Albuquerque, NM, USA.
Guy G BrusselleDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
James D CrapoDivision of Pulmonary and Critical Care Medicine, Department of Medicine, National Jewish Health, Denver, CO, USA.
Kim de JongUniversity of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, the Netherlands.ORCID http://orcid.org/0000-0002-3948-1046
Dawn L DeMeoChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Tasha E FingerlinCenter for Genes, Environment and Health, National Jewish Health, Denver, CO, USA.
Sina A GharibComputational Medicine Core, Center for Lung Biology, UW Medicine Sleep Center, Department of Medicine, University of Washington, Seattle, WA, USA.
Amund GulsvikDepartment of Clinical Science, University of Bergen, Bergen, Norway.
Ian P HallDivision of Respiratory Medicine, Queen's Medical Centre, University of Nottingham, Nottingham, UK.
John E HokansonDepartment of Epidemiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Woo Jin KimDepartment of Internal Medicine and Environmental Health Center, School of Medicine, Kangwon National University, Chuncheon, South Korea.
David A LomasUCL Respiratory, University College London, London, UK.
Stephanie J LondonEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Raleigh, NC, USA.ORCID http://orcid.org/0000-0003-4911-5290
Deborah A MeyersDepartment of Medicine, University of Arizona, Tucson, AZ, USA.
George T O'ConnorNational Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA, USA.
Stephen I RennardPulmonary, Critical Care, Sleep and Allergy Division, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
David A SchwartzDepartment of Medicine, School of Medicine, University of Colorado Denver, Aurora, CO, USA.ORCID http://orcid.org/0000-0001-6743-8443
Pawel Sliwinski2nd Department of Respiratory Medicine, Institute of Tuberculosis and Lung Diseases, Warsaw, Poland.
David SparrowVA Boston Healthcare System and Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
David P StrachanPopulation Health Research Institute, St. George's University of London, London, UK.ORCID http://orcid.org/0000-0001-7854-1366
Ruth Tal-SingerGlaxoSmithKline R&D, Collegeville, PA, USA.ORCID http://orcid.org/0000-0002-5275-8062
Yohannes TesfaigziLovelace Respiratory Research Institute, Albuquerque, NM, USA.
Jørgen VestboSchool of Biological Sciences, University of Manchester, Manchester, UK.
Judith M VonkUniversity of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, the Netherlands.
Jae-Joon YimDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Xiaobo ZhouChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Yohan BosséInstitut Universitaire de Cardiologie et de Pneumologie de Québec, Québec, Quebec, Canada.
Ani ManichaikulCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
Lies LahousseDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0002-3494-4363
Edwin K SilvermanChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.
H Marike BoezenUniversity of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, the Netherlands.
Louise V WainGenetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, UK.
Martin D TobinGenetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, UK.ORCID http://orcid.org/0000-0002-3596-7874
Brian D Hobbs *Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0001-9564-0745
Michael H Cho *Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA. remhc@channing.harvard.edu.ORCID http://orcid.org/0000-0002-4907-1657
SpiroMeta Consortium
International COPD Genetics Consortium
Brigham and Women's Hospital · USUniversity of Leicester · GBUniversitätsmedizin Greifswald · DEUniversity Medical Center Groningen · NLBoston University · USUlsan College · KRUniversity of Nottingham · GBNational Institutes of Health · USNational Jewish Health · USCentre for Human Genetics · GBLovelace Respiratory Research Institute · USScience for Life Laboratory · SESeoul National University · KRSwiss Tropical and Public Health Institute · CHUniversity of Arizona · USUniversity of British Columbia · CAUniversity of Cambridge · GBMaastricht University · NLTampere University · FIUniversity of Bergen · NO
Funding
MULTIDISCIPLINARY RESPIRATORY DISEASES RESEARCH TRAININGT32HL007085 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI ELLEN L BURNHAM, LISA A MAIER · 1985 to 2026
$21.6MGenetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M(2 of 2) Genetic Epidemiology of COPDR01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2012 to 2016
$18.9MRole of Genetics in Idiopathic Pulmonary Fibrosis (IPF)R01HL097163 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI FINGERLIN, TASHA E., SCHWARTZ, DAVID ALBERT · 2009 to 2018
$16.4MSystems Biology of Airway DiseaseP01HL132825 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WEISS, SCOTT T · 2016 to 2020
$12.6MSystems Biology, Bioinformatics, and BiostatisticsP01HL105339 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2011 to 2015
$12.2MGenetic and Genomic Characterization of the Occurrence and Progression of Interstitial Lung AbnormalitiesR01HL135142 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL H. CHO, GARY MATTHEW HUNNINGHAKE · 2017 to 2026
$7.7MGenetics and Environment in Adult Respiratory, Allergic and Cardiac diseaseZIAES043012 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI LONDON, STEPHANIE · 2009 to 2025
$6.4MInterstitial Lung Abnormalities: Defining the Phenotype, Causes, and Consequences.R01HL111024 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI HUNNINGHAKE, GARY MATTHEW · 2013 to 2022
$6.4MIdentifying Genetic Determinants of Severe, Early-Onset COPDR01HL113264 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CHO, MICHAEL H., SILVERMAN, EDWIN K · 2012 to 2016
$6.0MIdentifying functional variants in COPD GWAS lociR01HL137927 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CHO, MICHAEL H., SILVERMAN, EDWIN K · 2017 to 2020
$3.5MGenetic Determinants of COPD in Diverse Ethnic GroupsR01HL084323 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2010
$2.6MBiotechnology and Biological Sciences Research Council BB/F019394/1Medical Research Council G0700704Medical Research Council G1000861Medical Research Council MC_PC_12010Medical Research Council MC_PC_17228Medical Research Council MC_QA137853Medical Research Council MC_UU_00007/10Medical Research Council MR/K026992/1Medical Research Council MR/N011317/1Medical Research Council MR/N024842/1Medical Research Council MR/S003762/1NHLBI NIH HHS K01 HL129039NHLBI NIH HHS K08 HL136928NHLBI NIH HHS P01 HL105339NHLBI NIH HHS P01 HL132825NHLBI NIH HHS R01 HL084323NHLBI NIH HHS R01 HL089856NHLBI NIH HHS R01 HL097163NHLBI NIH HHS R01 HL111024NHLBI NIH HHS R01 HL113264NHLBI NIH HHS R01 HL135142NHLBI NIH HHS R01 HL137927NHLBI NIH HHS R33 HL120770NHLBI NIH HHS T32 HL007085NHLBI NIH HHS U01 HL089856Wellcome Trust 202849/Z/16/Z
Abstract
Chronic obstructive pulmonary disease (COPD) is the leading cause of respiratory mortality worldwide. Genetic risk loci provide new insights into disease pathogenesis. We performed a genome-wide association study in 35,735 cases and 222,076 controls from the UK Biobank and additional studies from the International COPD Genetics Consortium. We identified 82 loci associated with P < 5 × 10
Indexed as
AdultAgedAsthmaCase-Control StudiesFemaleGene ExpressionGenetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansLungMaleMiddle AgedPhenotypePolymorphism, Single NucleotidePulmonary Disease, Chronic Obstructive
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