SynthesisNature genetics2019
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.
Erratum issuedAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 316 papers, 15 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
316citing papers in PubMed, 15 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
316 citing papers in PubMed, 15 syntheses or guidelines pooled it.
- Genome-Wide Association Studies of Hospitalized Influenza Identify Four Risk Loci and Reveal Shared and Unique Genetic Factors Compared With COVID-19.Influenza and other respiratory viruses · 2026Pooled it
- Multi-ancestry genome-wide association study and meta-analysis of lung function decline.Respiratory research · 2026Pooled it
- Genetic characterization of preschool wheeze phenotypes.The Journal of allergy and clinical immunology · 2025Pooled it
- Genetic variations in anti-diabetic drug targets and COPD risk: evidence from mendelian randomization.BMC pulmonary medicine · 2024Pooled it
- Exploiting meta-analysis of genome-wide interaction with serum 25-hydroxyvitamin D to identify novel genetic loci associated with pulmonary function.The American journal of clinical nutrition · 2024Pooled it
- Genome-wide association study of preserved ratio impaired spirometry (PRISm).The European respiratory journal · 2024Pooled it
- GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification.Nature genetics · 2023Pooled it
- Pan-cancer and cross-population genome-wide association studies dissect shared genetic backgrounds underlying carcinogenesis.Nature communications · 2023Pooled it
- Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk.Nature genetics · 2023Pooled it
- X chromosome associations with chronic obstructive pulmonary disease and related phenotypes: an X chromosome-wide association study.Respiratory research · 2023Pooled it
- Genetic association and causal inference between lung function and venous thromboembolism.Respiratory research · 2023Pooled it
- Pooled it
- Association between PMInternational journal of environmental research and public health · 2022Pooled it
- Pulmonary Function and Blood DNA Methylation: A Multiancestry Epigenome-Wide Association Meta-analysis.American journal of respiratory and critical care medicine · 2022Pooled it
- Pooled it
- Duration and severity of asthma-like episodes in young children vary by viral and bacterial triggers.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
- Genetic associations with alcohol drinking initiation and cessation in sub-Saharan African and African ancestry populations.Research square · 2026Article
- TET2 promotes monocyte inflammatory activation in asthma via ALKBH5-m6A regulation and PI3K signaling: evidence from m6A-SNP and single-cell analyses.Molecular genetics and genomics : MGG · 2026Article
- Plasma apolipoprotein E protein attenuates pulmonary fibrosis through LRP1 and PLAU dual receptor-mediated TGF-β/Smad inhibition.Journal of advanced research · 2026Article
- Genetic variants in pulmonary hypertension associated with chronic obstructive pulmonary disease.Current opinion in pulmonary medicine · 2026Review
256 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
- Erratum issued
Authors and funding
110 authors.
Nick Shrine *Department of Health Sciences, University of Leicester, Leicester, UK.ORCID http://orcid.org/0000-0003-3641-4371
Anna L Guyatt *Department of Health Sciences, University of Leicester, Leicester, UK.ORCID http://orcid.org/0000-0003-1860-6337
A Mesut Erzurumluoglu *Department of Health Sciences, University of Leicester, Leicester, UK.
Victoria E JacksonDepartment of Health Sciences, University of Leicester, Leicester, UK.
Brian D HobbsChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0001-9564-0745
Carl A MelbourneDepartment of Health Sciences, University of Leicester, Leicester, UK.
Chiara BatiniDepartment of Health Sciences, University of Leicester, Leicester, UK.
Katherine A FawcettDepartment of Health Sciences, University of Leicester, Leicester, UK.
Kijoung SongTarget Sciences, GlaxoSmithKline, Collegeville, PA, USA.
Phuwanat SakornsakolpatChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4308-0974
Xingnan LiDivision of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona, Tucson, AZ, USA.
Ruth BoxallNuffield Department of Population Health, University of Oxford, Oxford, UK.
Nicola F ReeveDepartment of Health Sciences, University of Leicester, Leicester, UK.
Ma'en ObeidatThe University of British Columbia Centre for Heart Lung Innovation, St Paul's Hospital, Vancouver, British Columbia, Canada.ORCID http://orcid.org/0000-0002-5443-2752
Jing Hua ZhaoCardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Matthias WielscherDepartment of Epidemiology and Biostatistics, MRC-PHE Centre for Environment & Health, School of Public Health, Imperial College London, London, UK.
Stefan WeissInterfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0002-3553-4315
Katherine A KentistouCentre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-5816-664X
James P CookDepartment of Biostatistics, University of Liverpool, Liverpool, UK.
Benjamin B SunMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-6347-2281
Jian ZhouFlatiron Institute, Simons Foundation, New York, NY, USA.
Jennie HuiBusselton Population Medical Research Institute, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.
Stefan KarraschInstitute of Epidemiology, Helmholtz Zentrum Muenchen-German Research Center for Environmental Health, Neuherberg, Germany.
Medea ImbodenSwiss Tropical and Public Health Institute, Basel, Switzerland.
Sarah E HarrisCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Jonathan MartenMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Stefan EnrothDepartment of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala Universitet, Uppsala, Sweden.ORCID http://orcid.org/0000-0002-5056-9137
Shona M KerrMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Ida SurakkaInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Veronique VitartMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-4991-3797
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
Richard J AllenDepartment of Health Sciences, University of Leicester, Leicester, UK.ORCID http://orcid.org/0000-0002-8450-3056
Per S BakkeDepartment of Clinical Science, University of Bergen, Bergen, Norway.
Terri H BeatyDepartment of Epidemiology, Johns Hopkins University School of Public Health, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-7644-1705
Eugene R BleeckerDivision of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona, Tucson, AZ, USA.
Yohan BosséDepartment of Molecular Medicine, Laval University, Québec, Canada.ORCID http://orcid.org/0000-0002-3067-3711
Corry-Anke BrandsmaUniversity of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, GRIAC Research Institute, University of Groningen, Groningen, The Netherlands.
Zhengming ChenNuffield Department of Population Health, University of Oxford, Oxford, UK.
James D CrapoNational Jewish Health, Denver, CO, USA.
John DaneshMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Dawn L DeMeoChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Frank DudbridgeDepartment of Health Sciences, University of Leicester, Leicester, UK.
Ralf EwertDepartment of Internal Medicine B - Cardiology, Intensive Care, Pulmonary Medicine and Infectious Diseases, University Medicine Greifswald, Greifswald, Germany.
Christian GiegerResearch Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health, Neuherberg, Germany.
Amund GulsvikDepartment of Clinical Science, University of Bergen, Bergen, Norway.
Anna L HansellCentre for Environmental Health & Sustainability, University of Leicester, Leicester, UK.
Ke HaoDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Joshua D HoffmanTarget Sciences, GlaxoSmithKline, Collegeville, PA, USA.
John E HokansonDepartment of Epidemiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Georg HomuthInterfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Peter K JoshiCentre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-6361-5059
Philippe JoubertInstitut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Québec, Canada.
Claudia LangenbergMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Xuan LiThe University of British Columbia Centre for Heart Lung Innovation, St Paul's Hospital, Vancouver, British Columbia, Canada.
Liming LiDepartment of Epidemiology & Biostatistics, Peking University Health Science Center, Beijing, China.
Kuang LinNuffield Department of Population Health, University of Oxford, Oxford, UK.
Lars LindDepartment of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala, Sweden.
Nicholas LocantoreGSK R&D, Collegeville, PA, USA.
Jian'an LuanMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Anubha MahajanWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-5585-3420
Joseph C MaranvilleMRL, Merck & Co., Inc, Kenilworth, NJ, USA.
Alison MurrayThe Institute of Medical Sciences, Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, UK.ORCID http://orcid.org/0000-0003-4915-4847
David C NickleMRL, Merck & Co., Inc, Kenilworth, NJ, USA.
Richard PackerDepartment of Health Sciences, University of Leicester, Leicester, UK.
Margaret M ParkerChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Megan L PayntonDepartment of Health Sciences, University of Leicester, Leicester, UK.
David J PorteousCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-1249-6106
Dmitry ProkopenkoChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Dandi QiaoChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Rajesh RawalResearch Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health, Neuherberg, Germany.
Heiko RunzMRL, Merck & Co., Inc, Kenilworth, NJ, USA.
Ian SayersDivision of Respiratory Medicine and NIHR-Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UK.ORCID http://orcid.org/0000-0001-5601-5410
Don D SinThe University of British Columbia Centre for Heart Lung Innovation, St Paul's Hospital, Vancouver, British Columbia, Canada.
Blair H SmithDivision of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.ORCID http://orcid.org/0000-0002-5362-9430
María Soler ArtigasPsychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.
David SparrowVA Boston Healthcare System, Boston, MA, USA.
Ruth Tal-SingerGSK R&D, Collegeville, PA, USA.ORCID http://orcid.org/0000-0002-5275-8062
Paul R H J TimmersCentre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-5197-1267
Maarten Van den BergeUniversity of Groningen, University Medical Center Groningen, Department of Pulmonology, GRIAC Research Institute, University of Groningen, Groningen, The Netherlands.
John C WhittakerTarget Sciences - R&D, GSK Medicines Research Centre, Stevenage, UK.
Prescott G WoodruffUCSF Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California, San Francisco, CA, USA.
Laura M Yerges-ArmstrongTarget Sciences, GlaxoSmithKline, Collegeville, PA, USA.
Olga G TroyanskayaDepartment of Computer Science, Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0000-0002-5676-5737
Olli T RaitakariDepartment of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.
Mika KähönenDepartment of Clinical Physiology, Tampere University Hospital, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
Ozren PolašekCentre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Ulf GyllenstenDepartment of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala Universitet, Uppsala, Sweden.
Igor RudanCentre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-6993-6884
Ian J DearyCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Nicole M Probst-HenschSwiss Tropical and Public Health Institute, Basel, Switzerland.
Holger SchulzInstitute of Epidemiology, Helmholtz Zentrum Muenchen-German Research Center for Environmental Health, Neuherberg, Germany.
Alan L JamesBusselton Population Medical Research Institute, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.
James F WilsonCentre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-5751-9178
Beate StubbeDepartment of Internal Medicine B - Cardiology, Intensive Care, Pulmonary Medicine and Infectious Diseases, University Medicine Greifswald, Greifswald, Germany.
Eleftheria ZegginiWellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0003-4238-659X
Marjo-Riitta JarvelinDepartment of Epidemiology and Biostatistics, MRC-PHE Centre for Environment & Health, School of Public Health, Imperial College London, London, UK.
Nick WarehamMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Edwin K SilvermanChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Caroline HaywardMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-9405-9550
Andrew P MorrisDepartment of Biostatistics, University of Liverpool, Liverpool, UK.ORCID http://orcid.org/0000-0002-6805-6014
Adam S ButterworthMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-6915-9015
Robert A ScottTarget Sciences - R&D, GSK Medicines Research Centre, Stevenage, UK.
Robin G WaltersNuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-9179-0321
Deborah A MeyersDivision of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona, Tucson, AZ, USA.
Michael H ChoChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4907-1657
David P StrachanPopulation Health Research Institute, St George's, University of London, London, UK.ORCID http://orcid.org/0000-0001-7854-1366
Ian P Hall *Division of Respiratory Medicine and NIHR-Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UK.
Martin D Tobin *Department of Health Sciences, University of Leicester, Leicester, UK. mt47@leicester.ac.uk.ORCID http://orcid.org/0000-0002-3596-7874
Louise V Wain *Department of Health Sciences, University of Leicester, Leicester, UK. lvw1@leicester.ac.uk.ORCID http://orcid.org/0000-0003-4951-1867
Understanding Society Scientific Group
Funding
Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9MMetabolomic signatures of empysema and COPD progression in the COPDGene cohortR01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2012 to 2016
$31.1MGenetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7MGenetic and Genomic Characterization of the Occurrence and Progression of Interstitial Lung AbnormalitiesR01HL135142 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL H. CHO, GARY MATTHEW HUNNINGHAKE · 2017 to 2026
$7.7MInterstitial Lung Abnormalities: Defining the Phenotype, Causes, and Consequences.R01HL111024 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI HUNNINGHAKE, GARY MATTHEW · 2013 to 2022
$6.4MIdentifying Genetic Determinants of Severe, Early-Onset COPDR01HL113264 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CHO, MICHAEL H., SILVERMAN, EDWIN K · 2012 to 2016
$6.0MMulti-omic Subtyping of Chronic Obstructive Pulmonary DiseaseK08HL136928 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI HOBBS, BRIAN DANIEL · 2017 to 2021
$864kNetwork-based Methods for Understanding Genetic Determinants and Epistasis in COPDK01HL129039 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI QIAO, DANDI · 2015 to 2019
$844kBiotechnology and Biological Sciences Research Council BB/F019394/1British Heart Foundation RG/13/13/30194British Heart Foundation RG/18/13/33946Medical Research Council 1508647Medical Research Council G0700704Medical Research Council G1000861Medical Research Council G1001799Medical Research Council MC_PC_12010Medical Research Council MC_PC_13049Medical Research Council MC_PC_14135Medical Research Council MC_U137686851Medical Research Council MC_UU_00007/10Medical Research Council MC_UU_00017/1Medical Research Council MC_UU_12015/1Medical Research Council MC_UU_12026/2Medical Research Council MR/K026992/1Medical Research Council MR/N01104X/1Medical Research Council MR/N01104X/2Medical Research Council MR/N011317/1Medical Research Council MR/S003762/1NHLBI NIH HHS K01 HL129039NHLBI NIH HHS K08 HL136928NHLBI NIH HHS R01 HL089897NHLBI NIH HHS R01 HL111024NHLBI NIH HHS R01 HL113264NHLBI NIH HHS R01 HL135142NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897Wellcome Trust 202849/Z/16/ZWellcome Trust 212946/Z/18/Z
Abstract
Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of European ancestry, we define 279 lung function signals, 139 of which are new. In combination, these variants strongly predict COPD in independent populations. Furthermore, the combined effect of these variants showed generalizability across smokers and never smokers, and across ancestral groups. We highlight biological pathways, known and potential drug targets for COPD and, in phenome-wide association studies, autoimmune-related and other pleiotropic effects of lung function-associated variants. This new genetic evidence has potential to improve future preventive and therapeutic strategies for COPD.
Indexed as
AgedAged, 80 and overCase-Control StudiesFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansLungMaleMiddle AgedPolymorphism, Single NucleotidePulmonary Disease, Chronic ObstructiveRisk FactorsSmoking
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