ArticleNature microbiology2019
Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host.
Article in Nature microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 206 papers.
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206 citing papers in PubMed, 346 citations in OpenAlex.
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- Senescent Factors Suppress Innate Antiviral Immunity in Aged Mice via Two Distinct Mechanisms.Aging cell · 2026Article
- Cardiometabolic adaptations in the cave nectar bat Eonycteris spelaea.Communications biology · 2026Article
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- Interacting effects of sex and age on immune responses in a polygynous bat with male-biased mortality.bioRxiv : the preprint server for biology · 2026Article
- Adapting flow cytometry for studying immune cell seasonality in wild migratory bats.bioRxiv : the preprint server for biology · 2026Article
- Cloning, expression and characterisation of antigen-specific recombinant bat immunoglobulin from the black flying fox (Frontiers in immunology · 2026Article
- Metabolomics-constrained modelling reveals dominant oxidative metabolism in the Egyptian fruit bat myocardium.PloS one · 2026Article
- Annotation of bat IG H/L/K loci and analysis of the characteristics of bat BCR-CDR3 repertoires.Frontiers in immunology · 2026Article
- Exploratory metatranscriptomic survey of bat-associated RNA viruses in Quzhou city, China.Frontiers in veterinary science · 2026Article
- Comparative transcriptome analysis unveils unique antiviral immune signatures ofFrontiers in immunology · 2026Article
- Cellular and immune adaptations at the maternal-fetal interface in bats.Cell reports · 2025Article
- Systemic Effects of Pesticides on Insectivorous Bats: A Proteomics Approach.Integrative and comparative biology · 2025Article
- Bat power-metabolic profiling of the Egyptian fruit batbioRxiv : the preprint server for biology · 2025Article
- Single-cell analysis of intermediate horseshoe bat (Rhinolophus affinis) organs reveals viral infections and antiviral immune signatures.BMC genomics · 2025Article
146 more citing papers are in PubMed but not listed here.
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Authors and funding
17 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bats are special in their ability to host emerging viruses. As the only flying mammal, bats endure high metabolic rates yet exhibit elongated lifespans. It is currently unclear whether these unique features are interlinked. The important inflammasome sensor, NLR family pyrin domain containing 3 (NLRP3), has been linked to both viral-induced and age-related inflammation. Here, we report significantly dampened activation of the NLRP3 inflammasome in bat primary immune cells compared to human or mouse counterparts. Lower induction of apoptosis-associated speck-like protein containing a CARD (ASC) speck formation and secretion of interleukin-1β in response to both 'sterile' stimuli and infection with multiple zoonotic viruses including influenza A virus (-single-stranded (ss) RNA), Melaka virus (PRV3M, double-stranded RNA) and Middle East respiratory syndrome coronavirus (+ssRNA) was observed. Importantly, this reduction of inflammation had no impact on the overall viral loads. We identified dampened transcriptional priming, a novel splice variant and an altered leucine-rich repeat domain of bat NLRP3 as the cause. Our results elucidate an important mechanism through which bats dampen inflammation with implications for longevity and unique viral reservoir status.
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