ReviewNature biotechnology2019
Accessing analytes in biofluids for peripheral biochemical monitoring.
Review in Nature biotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 249 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
249 citing papers in PubMed.
- Real-Time Monitoring with a Wristwatch-Type Sodium- and Potassium-Ion Sensor Using a Screen-Printed Liquid-Junction Reference Electrode.ACS omega · 2026Article
- Wearable bioelectronics enabled by conductive hydrogels: From materials innovation to clinical translation.Materials today. Bio · 2026Review
- Vitiligo-like depigmentation as an accessible readout of antitumour immunity in melanoma immunotherapy.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Review
- Preserving Sample, Interface, and Signal Fidelity in Wearable Sweat Electrolyte Monitoring During Exercise.Biosensors · 2026Review
- Self-Powered Triboelectric Biofluid Sensors for Early Disease Screening and Diagnosis: A Review.Nanomaterials (Basel, Switzerland) · 2026Review
- Microfluidic valves for wearable sweat analysis: a review.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2026Review
- Best practices for using biological data in psychological research.Journal of mood and anxiety disorders · 2026Review
- Saliva, Sweat, and Exhaled Breath as Alternative Specimens for Exercise Chemistry: Analytical Advantages, Limitations, and Comparative Progress.Biomedical chromatography : BMC · 2026Review
- Point-of-Care Assessment of Kidney Function in Chronic Kidney Disease: Current Technologies and Future Perspectives.Medical sciences (Basel, Switzerland) · 2026Review
- Spiderweb-inspired electronically conductive hygroscopic adhesive for chronic bioelectronic interface.Science advances · 2026Article
- AI-Ready Multimodal Wearable Biosensors Beyond Glucose: Biofluid Sampling, Sensor Fusion, and Clinical Translation.Biosensors · 2026Review
- Applications of Wearable Sweat Biosensors in Sports Activities with Real-World Cases.Bioengineering (Basel, Switzerland) · 2026Review
- Advances and Challenges in Wearable Sensors for Health Monitoring.ACS applied materials & interfaces · 2026Review
- Wireless light-gated photoelectrochemical microneedle wearables for zero-bias longitudinal monitoring in interstitial fluid.Nature communications · 2026Article
- Interstitial fluid N-glycans serve as a proxy for serum biomarker discovery in a pilot study.Scientific reports · 2026Article
- Extraoral Detection of Biomarkers and Pathogens in Saliva: Comprehensive, Panoramic Review.Biosensors · 2026Review
- Review
- A Minimally Invasive, Subcutaneous Biosensor Reliably Estimates Plasma Methotrexate Exposure and Quantifies Plasma-to-Tissue Transport Kinetics.ACS pharmacology & translational science · 2026Article
- An enzymatic BioBattery based on multicopper oxidases with reduced substrate diffusion constraints for sustainable energy harvesting.Scientific reports · 2026Article
- Biomolecular profiling for noninvasive health monitoring.Nature biotechnology · 2026Review
189 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peripheral biochemical monitoring involves the use of wearable devices for minimally invasive or noninvasive measurement of analytes in biofluids such as interstitial fluid, saliva, tears and sweat. The goal in most cases is to obtain measurements that serve as surrogates for circulating analyte concentrations in blood. Key technological developments to date include continuous glucose monitors, which use an indwelling sensor needle to measure glucose in interstitial fluid, and device-integrated sweat stimulation for continuous access to analytes in sweat. Further development of continuous sensing technologies through new electrochemical sensing modalities will be a major focus of future research. While there has been much investment in wearable technologies to sense analytes, less effort has been directed to understanding the physiology of biofluid secretion. Elucidating the underlying biology is crucial for accelerating technological progress, as the biofluid itself often presents the greatest challenge in terms of sample volumes, secretion rates, filtration, active analyte channels, variable pH and salinity, analyte breakdown and other confounding factors.
Indexed as
Identifiers
30804536What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.