ArticleNature neuroscience2019
Divergent medial amygdala projections regulate approach-avoidance conflict behavior.
Article in Nature neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
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Who cites it
73 citing papers in PubMed.
- Hypothalamic representation of aggressiveness across mouse strains.Nature communications · 2026Article
- Autism with social anxiety is associated with acquiescent behaviors and enlarged amygdala volume.Translational psychiatry · 2026Article
- DRD1 and DRD2 dopamine-sensitive neurons in the central amygdala respond differently to rewarding and aversive stimuli.Translational psychiatry · 2026Article
- The posteroventral part of the medial amygdala nucleus glutamatergic neurons encodes conspecifics' individual identity in rodents.Science advances · 2026Article
- Dopamine modulation of aggression.Psychopharmacology · 2026Review
- Adolescent isolation disrupts medial amygdala and ventral tegmental area maturation and sex-specifically dysregulates transcriptional responses to cocaine and stress.Neuropharmacology · 2025Article
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- Estrogen Control of Social Behaviors.Annual review of neuroscience · 2025Review
- Brain circuits that regulate social behavior.Molecular psychiatry · 2025Review
- Repeated social stress increases posterior medial amygdala neuronal activity in stress-susceptible adult male rats.Journal of neurophysiology · 2025Article
- The human olfactory amygdala: Anatomical connections between the olfactory bulb and amygdala subregions.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- How Distributed Subcortical Integration of Reward and Threat May Inform Subsequent Approach-Avoidance Decisions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Oxytocin treatment rescues irritability-like behavior in Cc2d1a conditional knockout mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Distinct Neuromodulatory Effects of Endogenous Orexin and Dynorphin Corelease on Projection-Defined Ventral Tegmental Dopamine Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Distinct medial amygdala oxytocin receptor neurons projections respectively control consolation or aggression in male mandarin voles.Nature communications · 2024Article
- Activation of androgen receptor-expressing neurons in the posterior medial amygdala is associated with stress resistance in dominant male hamsters.Hormones and behavior · 2024Article
- Distinct glutamatergic projections of the posteroventral medial amygdala play different roles in arousal and anxiety.JCI insight · 2024Article
- Article
- Genetic disruption of dopamine β-hydroxylase dysregulates innate responses to predator odor in mice.Neurobiology of stress · 2024Article
13 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
Funding
Abstract
Avoidance of innate threats is often in conflict with motivations to engage in exploratory approach behavior. The neural pathways that mediate this approach-avoidance conflict are not well resolved. Here we isolated a population of dopamine D1 receptor (D1R)-expressing neurons within the posteroventral region of the medial amygdala (MeApv) in mice that are activated either during approach or during avoidance of an innate threat stimulus. Distinct subpopulations of MeApv-D1R neurons differentially innervate the ventromedial hypothalamus and bed nucleus of the stria terminalis, and these projections have opposing effects on investigation or avoidance of threatening stimuli. These projections are potently modulated through opposite actions of D1R signaling that bias approach behavior. These data demonstrate divergent pathways in the MeApv that can be differentially weighted toward exploration or evasion of threats.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.