Evidence map›Paper›PMID 30804502›Full record

ArticleNature cell biology2019

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

Kyosuke Nakamura, Giulia Saredi, Jordan R Becker, Benjamin M Foster, Nhuong V Nguyen, Tracey E Beyer, Laura C Cesa, Peter A Faull, Saulius Lukauskas, Thomas Frimurer and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Nature cell biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 140 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
140citing papers in PubMed, 1 pooled it
9.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

140 citing papers in PubMed, 1 synthesis or guideline pooled it, 197 citations in OpenAlex.

  1. Summary ofGenes · 2020
    Pooled it
  2. DNA Repair Mechanisms.Methods in molecular biology (Clifton, N.J.) · 2027
    Review
  3. Review
  4. Article
  5. TheBiomolecular NMR assignments · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Saturation genome editing ofmedRxiv : the preprint server for health sciences · 2025
    Article
  20. Article

80 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 4 countries.

Kyosuke NakamuraBiotech Research and Innovation Centre, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-1809-639X
Giulia SarediBiotech Research and Innovation Centre, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Jordan R BeckerWellcome Centre For Human Genetics, Oxford, UK.
Benjamin M FosterInstitute of Functional Epigenetics, Helmholtz Zentrum München, Neuherberg, Germany.
Nhuong V NguyenMRC London Institute of Medical Sciences, London, UK.ORCID http://orcid.org/0000-0003-4152-5113
Tracey E BeyerBiotech Research and Innovation Centre, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Laura C CesaBiotech Research and Innovation Centre, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Peter A FaullMRC London Institute of Medical Sciences, London, UK.ORCID http://orcid.org/0000-0001-8491-8086
Saulius LukauskasInstitute of Functional Epigenetics, Helmholtz Zentrum München, Neuherberg, Germany.
Thomas FrimurerNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
J Ross ChapmanWellcome Centre For Human Genetics, Oxford, UK.ORCID http://orcid.org/0000-0002-6477-4254
Till BartkeInstitute of Functional Epigenetics, Helmholtz Zentrum München, Neuherberg, Germany. till.bartke@helmholtz-muenchen.de.ORCID http://orcid.org/0000-0002-6584-2140
Anja GrothBiotech Research and Innovation Centre, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. anja.groth@bric.ku.dk.ORCID http://orcid.org/0000-0003-0577-1771
University of Copenhagen · DKHelmholtz Zentrum München · DECentre for Human Genetics · GBMRC London Institute of Medical Sciences · GBThe Francis Crick Institute · GB

Funding

Cancer Research UK 19270Medical Research Council MC_UP_1102/2
6 · The paper itself

Abstract

Genotoxic DNA double-strand breaks (DSBs) can be repaired by error-free homologous recombination (HR) or mutagenic non-homologous end-joining

Indexed as

Homologous RecombinationAmino Acid SequenceBRCA1 ProteinCell Line, TumorChromatidsDNA Breaks, Double-StrandedDNA RepairG2 PhaseHCT116 CellsHeLa CellsHistonesHumansLysineMethylationSequence Homology, Amino AcidS PhaseBARD1 protein, humanBRCA1 ProteinHistonesLysineTumor Suppressor ProteinsUbiquitin-Protein Ligases

Identifiers

PMID30804502
PMCPMC6420097
OpenAlexW2915095776

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.