ArticleNature communications2019
A linear nonribosomal octapeptide from Fusarium graminearum facilitates cell-to-cell invasion of wheat.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed, 120 citations in OpenAlex.
- Apicidin is a key virulence determinant of Fusarium asiaticum in wheat-rice cropping systems.Science China. Life sciences · 2026Article
- An ABC-B Transporter Helps ProtectJournal of fungi (Basel, Switzerland) · 2026Article
- Comparative analysis towards the identification of genome wide characteristics of a beneficial fungal endophyte.Scientific reports · 2026Article
- A functional atlas of secondary metabolite biosynthetic gene clusters governing growth, stress adaptation, and pathogenicity in Fusarium graminearum.Crop health · 2026Article
- High bacterial diversity drives the suppression of a soilborne plant disease.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Molecular Strategies and Regulatory Networks in the Early Infection Stages of Plant Pathogenic Fusarium Species.The plant pathology journal · 2026Review
- The phenol-2-monooxygenase FgPhm1 regulates DON synthesis, pathogenicity and environmental stress response inVirulence · 2025Article
- A putative auxin efflux carrier FgAec1 contributes to the pathogenicity of Fusarium graminearum.BMC biology · 2025Article
- Gatekeepers and Gatecrashers of the Symplasm: Cross-Kingdom Effector Manipulation of Plasmodesmata in Plants.Plants (Basel, Switzerland) · 2025Review
- The TRAPPIII complex regulates development and virulence of Fusarium graminearum by coordinating autophagy and intracellular transport.PLoS pathogens · 2025Article
- Fumarylacetoacetate hydrolase targeted by a Fusarium graminearum effector positively regulates wheat FHB resistance.Nature communications · 2025Article
- Starship giant transposable elements cluster by host taxonomy using k-mer-based phylogenetics.G3 (Bethesda, Md.) · 2025Article
- Temporal Wheat Proteome Remodeling by Deoxynivalenol Reveals Novel Detoxification Signatures and Strategies Across Cultivars.Molecular & cellular proteomics : MCP · 2025Article
- A Toxin of Valsa mali Determines Virulence and Host Preference.Molecular plant pathology · 2025Article
- Wheat resistance to Fusarium head blight and breeding strategies.Crop health · 2025Review
- A TaSnRK1α-TaCAT2 model mediates resistance to Fusarium crown rot by scavenging ROS in common wheat.Nature communications · 2025Article
- Article
- Identification and Confirmation of Virulence Factor Production fromJournal of fungi (Basel, Switzerland) · 2024Article
- Transcription Factor and Protein Regulatory Network ofPlants (Basel, Switzerland) · 2024Article
- Integrated Transcriptomics-Proteomics Analysis Reveals the Response Mechanism ofJournal of fungi (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fusarium graminearum is a destructive wheat pathogen. No fully resistant cultivars are available. Knowledge concerning the molecular weapons of F. graminearum to achieve infection remains limited. Here, we report that deletion of the putative secondary metabolite biosynthesis gene cluster fg3_54 compromises the pathogen's ability to infect wheat through cell-to-cell penetration. Ectopic expression of fgm4, a pathway-specific bANK-like regulatory gene, activates the transcription of the fg3_54 cluster in vitro. We identify a linear, C- terminally reduced and D-amino acid residue-rich octapeptide, fusaoctaxin A, as the product of the two nonribosomal peptide synthetases encoded by fg3_54. Chemically-synthesized fusaoctaxin A restores cell-to-cell invasiveness in fg3_54-deleted F. graminearum, and enables colonization of wheat coleoptiles by two Fusarium strains that lack the fg3_54 homolog and are nonpathogenic to wheat. In conclusion, our results identify fusaoctaxin A as a virulence factor required for cell-to-cell invasion of wheat by F. graminearum.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.