ArticleScientific reports2019
Gut microbiota of the European Brown Hare (Lepus europaeus).
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 31 citations in OpenAlex.
- Full-Length 16S and 18S rRNA Long-Read Sequencing Reveals Gut Microbiome Diversity in the European Brown Hare (Lepus europaeus).Environmental microbiology reports · 2026Article
- Grass supplementation to a pellet-based diet fails to enrich gut microbiomes with wild-like functions in captive-bred hares.Microbiology spectrum · 2026Article
- Sympatric Lepus spp. in the central Italian Alps host significantly different gut microbiotas.Scientific reports · 2026Article
- Flavonoid Rutin Reduces Intestinal Inflammation in an Experimental Model of Parkinson's Disease.Neurotoxicity research · 2026Article
- Article
- Analysis of gut microbiota in three species belonging to different genera (Ecology and evolution · 2021Article
- Experimental validation of small mammal gut microbiota sampling from faeces and from the caecum after death.Heredity · 2021Article
- Article
- Individual fate and gut microbiome composition in the European wild rabbit (Oryctolagus cuniculus).Scientific reports · 2021Article
- Diverse methanogens, bacteria and tannase genes in the feces of the endangered volcano rabbit (PeerJ · 2021Article
- Uncovering the microbiome of invasive sympatric European brown hares and European rabbits in Australia.PeerJ · 2020Article
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diseases of the gastrointestinal tract due to changes in the bacterial flora have been described with increasing incidence in the European brown hare. Despite extensive demographic and phylogeographic research, little is known about the composition of its gut microbiota and how it might vary based on potential environmental or host factors. We analysed the intestinal and faecal microbiota of 3 hare populations by Illumina MiSeq 16S rRNA gene amplicon sequencing. The phyla and OTU abundance composition differed significantly between intestinal and faecal samples (PERMANOVA: P = 0.002 and P = 0.031, respectively), but in both sample types Firmicutes and Bacteroidetes dominated the microbial community composition (45.51% and 19.30% relative abundance). Intestinal samples contained an enrichment of Proteobacteria compared with faecal samples (15.71-fold change, P < 0.001). At OTU level, a significant enrichment with best BLAST hits to the Escherichia-Shigella group, Eubacterium limosum, Sphingomonas kyeonggiensis, Flintibacter butyricus and Blautia faecis were detected in intestinal samples (P < 0.05). In our statistical model, geographic location and possibly associated environmental factors had a greater impact on the microbiota composition than host factors. Population had a significant effect on the composition of abundant intestinal and faecal OTUs, and on the abundance of potential pathogenic bacteria of the family Enterobacteriaceae, regularly associated with intestinal dysbiosis in hares, in faecal samples. Our study is the first to describe the microbiota in brown hares and provides a foundation to generate hypothesis aiming to test the role of gut health in population fluctuations of the species.
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