Evidence map›Paper›PMID 30804463›Full record

ArticleJournal of human hypertension2020

The prospective relationship between prehypertension, race, and whole-brain white matter microstructure.

Ben Allen, Matthew F Muldoon, Peter J Gianaros, Julian F Thayer, J Richard Jennings

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of human hypertension, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ben AllenDepartment of Psychology, University of Tennessee, Knoxville, TN, USA. ballen50@utk.edu.
Matthew F MuldoonHeart and Vascular Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Peter J GianarosDepartment of Psychology, University of Pittsburgh, Pittsburgh, PA, USA.
Julian F ThayerDepartment of Psychology, The Ohio State University, Columbus, OH, USA.
J Richard JenningsDepartment of Psychiatry & Psychology, University of Pittsburgh, Pittsburgh, PA, USA.

Funding

CARDIOVASCULAR BEHAVIORAL MEDICINE RESEARCH TRAININGT32HL007560 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Peter J Gianaros, REBECCA C THURSTON · 1985 to 2026
$11.3M
Neurobiological pathways linking stress and emotion to atherosclerosisR01HL089850 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GIANAROS, PETER J · 2008 to 2016
$4.7M
The Brain as a Target for Pre and Essential HypertensionR01HL101959 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JENNINGS, JOHN RICHARD · 2010 to 2014
$2.1M
NHLBI NIH HHS R01 HL089850NHLBI NIH HHS R01 HL101959NHLBI NIH HHS T32 HL007560
6 · The paper itself

Abstract

Compared with whites, blacks develop hypertension earlier in life, progress from prehypertension to hypertension at an accelerated rate, and exhibit greater hypertension-mediated organ damage (e.g., kidney disease, stroke). In this paper, we tested whether the longitudinal associations between elevated systolic blood pressure and disruption of brain white matter structural integrity differ as a function of race. A community sample of 100 middle-aged adults with prehypertension underwent diffusion imaging to quantify indirect metrics of white matter structural integrity, including fractional anisotropy. Blood pressure and diffusion imaging measurements were collected at baseline and at a 2-year follow-up. Regression analyses showed that higher systolic blood pressure at baseline was associated with a decrease in fractional anisotropy over 2 years in blacks only (β = -0.51 [95% CI = -0.85, -0.16], t = -2.93, p = 0.004, ΔR

Indexed as

Blood Pressure DeterminationDiffusion Tensor ImagingHypertensionPrehypertensionWhite MatterBlack or African AmericanBlack PeopleBlood PressureDisease ProgressionFemaleFollow-Up StudiesHumansMaleMiddle AgedOutcome Assessment, Health CarePrognosis

Identifiers

PMID30804463
PMCPMC6708769

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.