Evidence map›Paper›PMID 30804442›Full record

ArticleScientific reports2019

Molecular mechanism of lysophosphatidic acid-induced hypertensive response.

Kuniyuki Kano, Hirotaka Matsumoto, Asuka Inoue, Hiroshi Yukiura, Motomu Kanai, Jerold Chun, Satoshi Ishii, Takao Shimizu, Junken Aoki

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Lysophosphatidic acid signaling via LPAJournal of neurochemistry · 2022
    Article
  5. Elucidating the binding mechanism of LPA species and analogs in an LPAJournal of molecular graphics & modelling · 2022
    Article
  6. Article
  7. An ATX-LPAiScience · 2021
    Article
  8. Article
  9. The LPAInternational journal of molecular sciences · 2021
    Review
  10. Review
  11. Lysolipids in Vascular Development, Biology, and Disease.Arteriosclerosis, thrombosis, and vascular biology · 2021
    Review
  12. Article
  13. Review
  14. GαExperimental & molecular medicine · 2020
    Review
  15. Crossing signals: bioactive lipids in the microvasculature.American journal of physiology. Heart and circulatory physiology · 2020
    Review
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Kuniyuki KanoLaboratory of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, 980-8578, Japan. k-kano@m.tohoku.ac.jp.
Hirotaka MatsumotoLaboratory of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, 980-8578, Japan.
Asuka InoueLaboratory of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, 980-8578, Japan.
Hiroshi YukiuraLaboratory of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, 980-8578, Japan.
Motomu KanaiSynthetic Organic Chemistry Laboratory, Graduate School of Pharmaceutical Sciences, University of Tokyo, Bunkyo-ku, Tokyo, 113-0033, Japan.ORCID 0000-0003-1977-7648
Jerold ChunSanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.
Satoshi IshiiDepartment of Immunology, Akita University Graduate School of Medicine, Akita, 010-8543, Japan.
Takao ShimizuDepartment of Lipid Signaling, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo, 162-8655, Japan.
Junken AokiLaboratory of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, 980-8578, Japan. jaoki@m.tohoku.ac.jp.
Tohoku University · JPAkita University · JPNational Center for Global Health and Medicine · JPSanford Burnham Prebys Medical Discovery Institute · USThe University of Tokyo · JP

Funding

Prenatal blood-borne lipids in post-hemorrhagic hydrocephalusR01NS084398 · NINDS · SCRIPPS RESEARCH INSTITUTE, THE · PI CHUN, JEROLD · 2014 to 2017
$2.6M
NINDS NIH HHS R01 NS084398
6 · The paper itself

Abstract

Lysophosphatidic acid (LPA) is a blood-derived bioactive lipid with numerous biological activities exerted mainly through six defined G protein-coupled receptors (LPA

Indexed as

Disease SusceptibilityAnimalsBiomarkersDisease Models, AnimalFluorescent Antibody TechniqueGTP-Binding Protein alpha Subunits, G12-G13HypertensionLysophospholipidsMicerho-Associated KinasesSignal TransductionBiomarkersGTP-Binding Protein alpha Subunits, G12-G13lysophosphatidic acidLysophospholipidsrho-Associated Kinases

Identifiers

PMID30804442
PMCPMC6389983
OpenAlexW2915469994

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.