ArticleScientific reports2019
Blubber transcriptome responses to repeated ACTH administration in a marine mammal.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- Elephant Seal Blubber Under Multiple Stressors: Persistent Organic Pollutants, Stress Hormones and Hydrostatic Pressure Alter Transcriptome, Lipolysis and Leptin Secretion.Environmental science & technology · 2026Article
- Optimized methods for obtaining sequencing-quality RNA from blubber of free-ranging cetaceans collected under field conditions.Conservation physiology · 2026Article
- Terrestrial Birth and Body Size Tune UCP1 Functionality in Seals.Molecular biology and evolution · 2024Article
- The plasma proteome reveals markers of recent and repeated stress in free-ranging seals.Conservation physiology · 2024Article
- Proteome profiling reveals opportunities to investigate biomarkers of oxidative stress and immune responses in blubber biopsies from free-ranging baleen whales.Conservation physiology · 2024Article
- Adrenal response to ACTH challenge alters thyroid and immune function and varies with body reserves in molting adult female northern elephant seals.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Comprehensive molecular and morphological resolution of blubber stratification in a deep-diving, fasting-adapted seal.Frontiers in physiology · 2022Article
- A deep dive into fat: Investigating blubber lipidomic fingerprint of killer whales and humpback whales in northern Norway.Ecology and evolution · 2021Article
- Ontogeny of Carbon Monoxide-Related Gene Expression in a Deep-Diving Marine Mammal.Frontiers in physiology · 2021Article
- Comparative genomics of cetartiodactyla: energy metabolism underpins the transition to an aquatic lifestyle.Conservation physiology · 2021Article
- A blubber gene expression index for evaluating stress in marine mammals.Conservation physiology · 2020Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic physiological stress impacts animal fitness by catabolizing metabolic stores and suppressing reproduction. This can be especially deleterious for capital breeding carnivores such as marine mammals, with potential for ecosystem-wide effects. However, the impacts and indicators of chronic stress in animals are currently poorly understood. To identify downstream mediators of repeated stress responses in marine mammals, we administered adrenocorticotropic hormone (ACTH) once daily for four days to free-ranging juvenile northern elephant seals (Mirounga angustirostris) to stimulate endogenous corticosteroid release, and compared blubber tissue transcriptome responses to the first and fourth ACTH administrations. Gene expression profiles were distinct between blubber responses to single and repeated ACTH administration, despite similarities in circulating cortisol profiles. We identified 61 and 12 genes that were differentially expressed (DEGs) in response to the first ACTH and fourth administrations, respectively, 24 DEGs between the first and fourth pre-ACTH samples, and 12 DEGs between ACTH response samples from the first and fourth days. Annotated DEGs were associated with functions in redox and lipid homeostasis, suggesting potential negative impacts of repeated stress on capital breeding, diving mammals. DEGs identified in this study are potential markers of repeated stress in marine mammals, which may not be detectable by endocrine profiles alone.
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